| Literature DB >> 27699784 |
Dhanasekaran Bodhini1, Manickam Chidambaram1, Samuel Liju1, Balakannan Revathi1, Dhandapani Laasya1, Natarajan Sathish1, Sekar Kanthimathi1, Saurabh Ghosh2, Ranjit Mohan Anjana1,3, Viswanathan Mohan1,3, Venkatesan Radha1.
Abstract
This study reports on the association of genetic variants selected from previous genome-wide association studies for type 2 diabetic nephropathy in south Indians. Eight variants were genotyped in 601 type 2 diabetic subjects without nephropathy (DM) and 583 type 2 diabetic subjects with nephropathy (DN) by MassARRAY. The minor allele frequencies of rs11643718 SLC12A3 variant and rs741301 ELMO1 variant were significantly different between DM and DN groups (P = 0.029 and 0.016, respectively). A combined analysis showed that the subjects carrying the risk genotypes of both these variants (GG of rs11643718 + AG/AA of rs741301) had a significant association with DN with an odds ratio [adjusted for age, sex, Body Mass Index (BMI), HbA1c, and systolic Blood Pressure (BP)] of 1.73 (1.30-2.30, P = 1.72 × 10-4 ) as compared to subjects carrying all other genotype combinations. This is the first study to report a significant association of the SLC12A3 rs11643718 and ELMO1 rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.Entities:
Keywords: Diabetic nephropathy; ELMO1 gene; SLC12A3 gene; South Indians; rs11643718; rs741301
Mesh：
Substances：
Year: 2016 PMID： 27699784 DOI： 10.1111/ahg.12174
Source DB: PubMed Journal: Ann Hum Genet ISSN： 0003-4800 Impact factor: 1.670