Kazuo Eguchi1. 1. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, 329-0498, Japan. ke112@jichi.ac.jp.
Abstract
PURPOSE OF REVIEW: The study aims to summarize the effect of antihypertensive therapy on various types of BP variability in hypertensives. RECENT FINDINGS: Visit-to-visit, day-by-day, and ambulatory BPV are markers of target organ damage and cardiovascular prognosis, as was shown in the LIFE study, which showed that visit-to-visit variability in BP predicted cardiovascular events in treated hypertensive patients with left ventricular hypertrophy. Long-acting calcium channel blockers (CCBs) may be a preferable treatment in reducing BPV measures. Non-adherence to antihypertensive medication is also a very important component of increased BPV, and improving the adherence is also a key for the favorable prognosis. BPV cannot be a target of antihypertensive treatments because of the lack of definitive evidence. However, in high-risk patients, those with cardiovascular or cerebrovascular diseases, the clinical significance should be considered in individual basis. Especially, reduction of BPV would be an important strategy for these patients.
PURPOSE OF REVIEW: The study aims to summarize the effect of antihypertensive therapy on various types of BP variability in hypertensives. RECENT FINDINGS: Visit-to-visit, day-by-day, and ambulatory BPV are markers of target organ damage and cardiovascular prognosis, as was shown in the LIFE study, which showed that visit-to-visit variability in BP predicted cardiovascular events in treated hypertensivepatients with left ventricular hypertrophy. Long-acting calcium channel blockers (CCBs) may be a preferable treatment in reducing BPV measures. Non-adherence to antihypertensive medication is also a very important component of increased BPV, and improving the adherence is also a key for the favorable prognosis. BPV cannot be a target of antihypertensive treatments because of the lack of definitive evidence. However, in high-risk patients, those with cardiovascular or cerebrovascular diseases, the clinical significance should be considered in individual basis. Especially, reduction of BPV would be an important strategy for these patients.
Entities:
Keywords:
Antihypertensive therapy; BPV; Blood pressure; Variability in blood pressure
Authors: Paul Muntner; Jeff Whittle; Amy I Lynch; Lisandro D Colantonio; Lara M Simpson; Paula T Einhorn; Emily B Levitan; Paul K Whelton; William C Cushman; Gail T Louis; Barry R Davis; Suzanne Oparil Journal: Ann Intern Med Date: 2015-09-01 Impact factor: 25.391
Authors: Alfonso Tatasciore; Giulia Renda; Marco Zimarino; Manola Soccio; Grzegorz Bilo; Gianfranco Parati; Giuseppe Schillaci; Raffaele De Caterina Journal: Hypertension Date: 2007-06-11 Impact factor: 10.190