Literature DB >> 27699111

Multiphoton excited hemoglobin fluorescence and third harmonic generation for non-invasive microscopy of stored blood.

Ilyas Saytashev1, Rachel Glenn1, Gabrielle A Murashova1, Sam Osseiran2, Dana Spence1, Conor L Evans3, Marcos Dantus4.   

Abstract

Red blood cells (RBC) in two-photon excited fluorescence (TPEF) microscopy usually appear as dark disks because of their low fluorescent signal. Here we use 15fs 800nm pulses for TPEF, 45fs 1060nm pulses for three-photon excited fluorescence, and third harmonic generation (THG) imaging. We find sufficient fluorescent signal that we attribute to hemoglobin fluorescence after comparing time and wavelength resolved spectra of other expected RBC endogenous fluorophores: NADH, FAD, biliverdin, and bilirubin. We find that both TPEF and THG microscopy can be used to examine erythrocyte morphology non-invasively without breaching a blood storage bag.

Entities:  

Keywords:  (180.0180) Microscopy; (180.4315) Nonlinear microscopy; (180.5810) Scanning microscopy

Year:  2016        PMID： 27699111      PMCID： PMC5030023          DOI： 10.1364/BOE.7.003449

Source DB:  PubMed          Journal:  Biomed Opt Express        ISSN： 2156-7085            Impact factor:   3.732


  31 in total

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