Literature DB >> 27697804

Haemophagocytic lymphohistiocytosis: an elusive syndrome.

William Thomas1, Mars Van't Veer2, Martin Besser2.   

Abstract

Haemophagocytic lymphohistiocytosis is a rare inflammatory condition. It can present in adult general medical patients and is a challenging diagnostic conundrum. This article provides an overview of the pathophysiology and clinical presentation of the syndrome for the general physician who will be rarely confronted with this problem but will have to act promptly when the situation arises. Treatment is also briefly discussed, although this usually occurs in a specialist setting after the diagnosis has been established. © Royal College of Physicians 2016. All rights reserved.

Entities:  

Keywords:  haemophagocytic lymphohistiocytosis; haemophagocytic syndrome; macrophage activation syndrome

Mesh：

Year:  2016        PMID： 27697804      PMCID： PMC6297301          DOI： 10.7861/clinmedicine.16-5-432

Source DB:  PubMed          Journal:  Clin Med (Lond)        ISSN： 1470-2118            Impact factor:   2.659


  12 in total

1.  Molecular basis of familial hemophagocytic lymphohistiocytosis.

Authors:  Valentina Cetica; Daniela Pende; Gillian M Griffiths; Maurizio Aricò
Journal:  Haematologica       Date:  2010-04       Impact factor: 9.941

2.  HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.

Authors:  Jan-Inge Henter; Annacarin Horne; Maurizio Aricó; R Maarten Egeler; Alexandra H Filipovich; Shinsaku Imashuku; Stephan Ladisch; Ken McClain; David Webb; Jacek Winiarski; Gritta Janka
Journal:  Pediatr Blood Cancer       Date:  2007-02       Impact factor: 3.167

Review 3.  How I treat hemophagocytic lymphohistiocytosis.

Authors:  Michael B Jordan; Carl E Allen; Sheila Weitzman; Alexandra H Filipovich; Kenneth L McClain
Journal:  Blood       Date:  2011-08-09       Impact factor: 22.113

4.  Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol.

Authors:  Helena Trottestam; Annacarin Horne; Maurizio Aricò; R Maarten Egeler; Alexandra H Filipovich; Helmut Gadner; Shinsaku Imashuku; Stephan Ladisch; David Webb; Gritta Janka; Jan-Inge Henter
Journal:  Blood       Date:  2011-09-06       Impact factor: 22.113

5.  Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation.

Authors:  Rebecca A Marsh; Gretchen Vaughn; Mi-Ok Kim; Dandan Li; Sonata Jodele; Sarita Joshi; Parinda A Mehta; Stella M Davies; Michael B Jordan; Jack J Bleesing; Alexandra H Filipovich
Journal:  Blood       Date:  2010-09-20       Impact factor: 22.113

6.  Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation.

Authors:  Jan-Inge Henter; AnnaCarin Samuelsson-Horne; Maurizio Aricò; R Maarten Egeler; Göran Elinder; Alexandra H Filipovich; Helmut Gadner; Shinsaku Imashuku; Diane Komp; Stephan Ladisch; David Webb; Gritta Janka
Journal:  Blood       Date:  2002-10-01       Impact factor: 22.113

Review 7.  Diagnostic evaluation of patients with suspected haemophagocytic lymphohistiocytosis.

Authors:  Kai Lehmberg; Stephan Ehl
Journal:  Br J Haematol       Date:  2012-12-04       Impact factor: 6.998

Review 8.  Hodgkin's lymphoma, Epstein-Barr virus reactivation and fatal haemophagocytic syndrome.

Authors:  S Hasselblom; A Linde; B Ridell
Journal:  J Intern Med       Date:  2004-02       Impact factor: 8.989

9.  Treatment of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) in young adults: a report from the HLH study center.

Authors:  Shinsaku Imashuku; Kikuko Kuriyama; Rika Sakai; Yoshitaka Nakao; Shin-ichi Masuda; Norimasa Yasuda; Fumio Kawano; Kimikazu Yakushijin; Akiko Miyagawa; Taisei Nakao; Tomoko Teramura; Yasuhiro Tabata; Akira Morimoto; Shigeyoshi Hibi
Journal:  Med Pediatr Oncol       Date:  2003-08

10.  Familial hemophagocytic lymphohistiocytosis may present during adulthood: clinical and genetic features of a small series.

Authors:  Elena Sieni; Valentina Cetica; Andrea Piccin; Filippo Gherlinzoni; Ferdinando Carlo Sasso; Marco Rabusin; Luciano Attard; Alberto Bosi; Daniela Pende; Lorenzo Moretta; Maurizio Aricò
Journal:  PLoS One       Date:  2012-09-07       Impact factor: 3.240
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  3 in total

1.  Secondary hemophagocytic syndrome after renal transplantation: two case-reports.

Authors:  José Narciso Júnior; Beatriz de Oliveira Neri; Gilberto Loiola de Alencar Dantas; Lara de Holanda Jucá Silveira; Maria Luiza de Mattos Brito Oliveira Sales; Tainá Veras de Sandes Freitas; Ronaldo de Matos Esmeraldo
Journal:  J Bras Nefrol       Date:  2019-07-18

Review 2.  A Review of Hemophagocytic Lymphohistiocytosis in Patients With HIV.

Authors:  Hussam Tabaja; Amjad Kanj; Said El Zein; Isin Yagmur Comba; Omar Chehab; Maryam Mahmood
Journal:  Open Forum Infect Dis       Date:  2022-02-11       Impact factor: 3.835

3.  A pilot study of ruxolitinib as a front-line therapy for 12 children with secondary hemophagocytic lymphohistiocytosis.

Authors:  Qing Zhang; Ang Wei; Hong-Hao Ma; Li Zhang; Hong-Yun Lian; Dong Wang; Yun-Ze Zhao; Lei Cui; Wei-Jing Li; Ying Yang; Tian-You Wang; Zhi-Gang Li; Rui Zhang
Journal:  Haematologica       Date:  2021-07-01       Impact factor: 9.941
  3 in total

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