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Literature DB >> 27697617

Alcohol-associated cancer and deregulation of Pol III genes.

Abstract

Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism of alcohol-promoted cell transformation and tumor development. Alcohol induces JNK1 activation and increases cellular levels of c-Jun to upregulate Brf1 expression and Pol III gene transcription, leading to an enhancement of rates of cell transformation and tumor formation.

Entities: CellLine Chemical Disease Gene Species

Keywords: Alcohol; Breast cancer; Brf1; HCC; Pol III genes

Mesh：

Substances：

Year: 2016 PMID： 27697617 PMCID： PMC5374039 DOI： 10.1016/j.gene.2016.09.046

Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688

33 in total

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Authors: Shuping Zhong; Keigo Machida; Hide Tsukamoto; Deborah L Johnson
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9. A meta-analysis of alcohol drinking and cancer risk.

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10 in total

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Journal: Liver Res Date: 2017-09-09

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4. Mitogen- and Stress-Activated Protein Kinase 1 Mediates Alcohol-Upregulated Transcription of Brf1 and tRNA Genes to Cause Phenotypic Alteration.

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Journal: Oxid Med Cell Longev Date: 2020-06-27 Impact factor: 6.543