| Literature DB >> 27697513 |
Sandeep Kumar1, Gaurav Bhanjana2, Arvind Kumar2, Kapila Taneja2, Neeraj Dilbaghi2, Ki-Hyun Kim3.
Abstract
The use of nanocarriers to enhance drug delivery efficacy has been increasing in the healthcare field due to their tunable surface properties. In this study, ceftriaxone-loaded solid lipid nanoparticles (CL-SLNPs) were synthesized using a water-in-oil-in-water (w/o/w) type double emulsification method. The formulation was optimized using response surface methodology (RSM) and was characterized using transmission electron microscopy (TEM), photon correlation spectroscopy (PCS), and UV-vis and Fourier transform infrared (FTIR) spectroscopy. The CL-SLNPs were of spherical shape, 15-20nm in size, and retained the properties of the drug or other constituents/ingredients after loading. The prepared nanoformulation offered sustained drug release after 24h, while ceftriaxone sodium followed a burst release. Antibacterial activity of the nanoformulation was evaluated against different gram-positive and gram-negative bacterial strains. The minimum inhibitory concentration of CL-SLNPs against Pseudomonas aeruginosa was determined as 31μg/mL.Entities:
Keywords: Antibacterial; Ceftriaxone sodium; Emulsification; Nanoformulation; Solid lipid nanoparticles
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Year: 2016 PMID： 27697513 DOI： 10.1016/j.chemphyslip.2016.09.002
Source DB: PubMed Journal: Chem Phys Lipids ISSN： 0009-3084 Impact factor: 3.329