Ana Santurtún1, Manuel Delgado-Alvarado2, Alejandro Villar3, Javier Riancho4. 1. Unidad de Medicina Legal, Departamento de Fisiología y Farmacología, Universidad de Cantabria, Santander, España. Electronic address: ana.santurtun@unican.es. 2. Área de Investigación de Neurociencias, Instituto de Investigación Sanitaria Biodonostia, San Sebastián, Guipúzcoa, España. 3. TICNOR S. L., Santander, España. 4. Servicio de Neurología, Hospital Universitario Marqués de Valdecilla-IDIVAL (CIBERNED), Santander, España.
Abstract
BACKGROUND AND OBJECTIVE: Parkinson's disease (PD) is the second most common neurodegenerative disease, and the etiology of its sporadic form is unknown. The present study analyzes the temporal and spatial variations of mortality by PD in Spain over a period of 14 years and its relationship with lead concentration levels in the atmosphere. METHOD: An ecological study was performed, in which deaths by PD and age group in 50 Spanish provinces between 2000 and 2013 were analyzed. The annual trend of PD mortality was assessed using the non-parametric Spearman's Rho test. Finally, the relationship between lead concentration levels in the air and mortality by PD was evaluated. RESULTS: Between 2000 and 2013, 36,180 patients with PD died in Spain. There is an increasing trend in mortality through PD over the study period (P<.0001). La Rioja, Asturias, Basque Country and the Lower Ebro valley were the regions with the highest values of PD mortality. Those regions with the highest lead concentrations also showed higher mortality by this disease in people over 64 (P=.02). CONCLUSIONS: Over our period of study, there has been an increase in mortality through PD in Spain, with the northernmost half of the country registering the highest values. Mortality in men was higher than mortality in women. Moreover, a direct correlation was found between lead levels in the air and mortality through PD.
BACKGROUND AND OBJECTIVE:Parkinson's disease (PD) is the second most common neurodegenerative disease, and the etiology of its sporadic form is unknown. The present study analyzes the temporal and spatial variations of mortality by PD in Spain over a period of 14 years and its relationship with lead concentration levels in the atmosphere. METHOD: An ecological study was performed, in which deaths by PD and age group in 50 Spanish provinces between 2000 and 2013 were analyzed. The annual trend of PDmortality was assessed using the non-parametric Spearman's Rho test. Finally, the relationship between lead concentration levels in the air and mortality by PD was evaluated. RESULTS: Between 2000 and 2013, 36,180 patients with PD died in Spain. There is an increasing trend in mortality through PD over the study period (P<.0001). La Rioja, Asturias, Basque Country and the Lower Ebro valley were the regions with the highest values of PDmortality. Those regions with the highest lead concentrations also showed higher mortality by this disease in people over 64 (P=.02). CONCLUSIONS: Over our period of study, there has been an increase in mortality through PD in Spain, with the northernmost half of the country registering the highest values. Mortality in men was higher than mortality in women. Moreover, a direct correlation was found between lead levels in the air and mortality through PD.
Authors: Mariana Oliveira; André Padrão; André Ramalho; Mariana Lobo; Ana Cláudia Teodoro; Hernâni Gonçalves; Alberto Freitas Journal: Int J Environ Res Public Health Date: 2020-11-13 Impact factor: 3.390
Authors: Ana María Jiménez-Cebrián; Ricardo Becerro-de-Bengoa-Vallejo; Marta Elena Losa-Iglesias; Daniel López-López; César Calvo-Lobo; Patricia Palomo-López; Carlos Romero-Morales; Emmanuel Navarro-Flores Journal: Int J Environ Res Public Health Date: 2021-03-01 Impact factor: 3.390