Triin Kaldur1, Eve Unt2, Vahur Ööpik3, Mihkel Zilmer4, Jaan Eha5, Kaido Paapstel4, Jaak Kals6. 1. Institute of Exercise Biology and Physiotherapy, University of Tartu, Tartu, Estonia; Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tartu, Estonia. Electronic address: triin.kaldur85@gmail.com. 2. Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tartu, Estonia; Department of Cardiology, University of Tartu, Tartu, Estonia; Department of Sports Medicine and Rehabilitation, University of Tartu, Tartu, Estonia; Sports Medicine and Rehabilitation Clinic, Tartu University Hospital, Tartu, Estonia. 3. Institute of Exercise Biology and Physiotherapy, University of Tartu, Tartu, Estonia; Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tartu, Estonia. 4. Institute of Biomedicine and Translational Medicine, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia. 5. Department of Cardiology, University of Tartu, Tartu, Estonia. 6. Institute of Biomedicine and Translational Medicine, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia; Department of Vascular Surgery, Tartu University Hospital, Tartu, Estonia.
Abstract
BACKGROUND AND OBJECTIVE: The aim of the study was to determine the acute effect of passive heat exposure (PHE) on arterial stiffness, oxidative stress (OxS) and inflammatory parameters. MATERIALS AND METHODS: Subjects were studied in thermoneutral conditions before and after PHE in a climatic chamber. Pulse wave analysis was used for assessment of central hemodynamic and arterial stiffness parameters. Venous blood samples were obtained to measure OxS and inflammatory parameters. RESULTS: Rectal temperature increased after PHE exposure compared to baseline: 37.01°C±0.19°C and 36.4°C±0.31°C, respectively (P<0.001). There was a 17% (P<0.05) decrease in large artery elasticity index (from 24.68±5.53 to 20.42±2.65mL/mmHg*10), which was predicted upon normothermic value (r=-0.878, P<0.01). However, no significant changes were found in others arterial stiffness parameters. A 30% (P<0.05) increase occurred in blood IL-6 concentration (from 0.43±0.15 to 0.56±0.23pg/mL), but OxS parameters remained significantly unchanged. CONCLUSIONS: This study describes for the first time acute PHE effects on arterial stiffness, inflammation and OxS. PHE significantly decreases large artery elasticity index and increases inflammatory IL-6 level. However, further larger investigations are needed for clarifying acute PHE effects on arterial function and biomarkers.
BACKGROUND AND OBJECTIVE: The aim of the study was to determine the acute effect of passive heat exposure (PHE) on arterial stiffness, oxidative stress (OxS) and inflammatory parameters. MATERIALS AND METHODS: Subjects were studied in thermoneutral conditions before and after PHE in a climatic chamber. Pulse wave analysis was used for assessment of central hemodynamic and arterial stiffness parameters. Venous blood samples were obtained to measure OxS and inflammatory parameters. RESULTS: Rectal temperature increased after PHE exposure compared to baseline: 37.01°C±0.19°C and 36.4°C±0.31°C, respectively (P<0.001). There was a 17% (P<0.05) decrease in large artery elasticity index (from 24.68±5.53 to 20.42±2.65mL/mmHg*10), which was predicted upon normothermic value (r=-0.878, P<0.01). However, no significant changes were found in others arterial stiffness parameters. A 30% (P<0.05) increase occurred in blood IL-6 concentration (from 0.43±0.15 to 0.56±0.23pg/mL), but OxS parameters remained significantly unchanged. CONCLUSIONS: This study describes for the first time acute PHE effects on arterial stiffness, inflammation and OxS. PHE significantly decreases large artery elasticity index and increases inflammatory IL-6 level. However, further larger investigations are needed for clarifying acute PHE effects on arterial function and biomarkers.
Authors: Aaron R Caldwell; Forrest B Robinson; Matthew A Tucker; Cash H Arcement; Cory L Butts; Brendon P McDermott; Matthew S Ganio Journal: Eur J Appl Physiol Date: 2017-06-13 Impact factor: 3.078