Philipe de Souto Barreto1,2, Matteo Cesari3,2, Yves Rolland3,2, Anne Sophie Salabert4,5, Pierre Payoux4,5, Sandrine Andrieu3,2, Bruno Vellas3,2. 1. Gerontopole of Toulouse, University Hospital of Toulouse (CHU Toulouse), France. philipebarreto81@yahoo.com.br. 2. UMR INSERM 1027, University of Toulouse III, France. 3. Gerontopole of Toulouse, University Hospital of Toulouse (CHU Toulouse), France. 4. Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France. 5. Department of Nuclear Medicine, University Hospital of Toulouse (CHU Toulouse), France.
Abstract
BACKGROUND: The objectives of this study were to examine the cross-sectional and prospective associations of muscle functional performance as assessed by a chair rise test and brain amyloid load among nondemented older adults with spontaneous memory complaints. METHODS: This is a secondary analysis, with an observational design, using data from the MAPT randomized controlled trial. Individuals assessed for brain amyloid load (florbetapir F18 positron emission tomography) and without clinical dementia (N = 269 aged 75.2±4.2 years; 60.2% women) participated in the study. Cortical and regional standard uptake value ratios (SUVRs) were obtained. The main outcome measure was the 5-repetition chair rise performance (maximum speed-higher is better), which was assessed at baseline and at 6, 12, 24, and 36 months. Adjusted multiple linear (cross-sectional) and mixed-effect (overtime) regressions were performed. RESULTS: Any of mean cortical (regions of interest) and each regional SUVRs (anterior cingulate, anterior putamen, caudate, hippocampus, medial orbitofrontal cortex, occipital cortex, parietal cortex, pons, posterior cingulate, posterior putamen, precuneus, semioval center, and temporal cortex) were not associated to chair rise after adjustment for multiplicity. These findings were obtained for both cross-sectional and prospective associations. CONCLUSIONS: Brain amyloid was not found to be associated to chair rise performance in nondemented older adults with memory complaints. Potential mechanisms on the links, if any, of amyloid load with physical performance are probably not dependent on muscle function.
RCT Entities:
BACKGROUND: The objectives of this study were to examine the cross-sectional and prospective associations of muscle functional performance as assessed by a chair rise test and brain amyloid load among nondemented older adults with spontaneous memory complaints. METHODS: This is a secondary analysis, with an observational design, using data from the MAPT randomized controlled trial. Individuals assessed for brain amyloid load (florbetapir F18 positron emission tomography) and without clinical dementia (N = 269 aged 75.2±4.2 years; 60.2% women) participated in the study. Cortical and regional standard uptake value ratios (SUVRs) were obtained. The main outcome measure was the 5-repetition chair rise performance (maximum speed-higher is better), which was assessed at baseline and at 6, 12, 24, and 36 months. Adjusted multiple linear (cross-sectional) and mixed-effect (overtime) regressions were performed. RESULTS: Any of mean cortical (regions of interest) and each regional SUVRs (anterior cingulate, anterior putamen, caudate, hippocampus, medial orbitofrontal cortex, occipital cortex, parietal cortex, pons, posterior cingulate, posterior putamen, precuneus, semioval center, and temporal cortex) were not associated to chair rise after adjustment for multiplicity. These findings were obtained for both cross-sectional and prospective associations. CONCLUSIONS: Brain amyloid was not found to be associated to chair rise performance in nondemented older adults with memory complaints. Potential mechanisms on the links, if any, of amyloid load with physical performance are probably not dependent on muscle function.
Authors: Sean A P Clouston; Katherine Jonas; Laura J Fochtmann; Evelyn J Bromet; Roman Kotov Journal: J Gerontol A Biol Sci Med Sci Date: 2020-06-18 Impact factor: 6.053
Authors: Lingxiao He; Philipe de Souto Barreto; Geetika Aggarwal; Andrew D Nguyen; John E Morley; Yan Li; Randall J Bateman; Bruno Vellas Journal: Alzheimers Res Ther Date: 2020-10-08 Impact factor: 6.982