Mark A Louter1, Leopoldine A Wilbrink1, Joost Haan1, Erik W van Zwet1, Willebrordus P J van Oosterhout1, Frans G Zitman1, Michel D Ferrari1, Gisela M Terwindt2. 1. From the Departments of Neurology (M.A.L., L.A.W., J.H., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L., F.G.Z.), and Biostatistics (E.W.v.Z.), Leiden University Medical Centre; Department of Neurosurgery (L.A.W.), Maastricht University Medical Centre; and Department of Neurology (J.H.), Alrijne Hospital, Leiderdorp, the Netherlands. 2. From the Departments of Neurology (M.A.L., L.A.W., J.H., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L., F.G.Z.), and Biostatistics (E.W.v.Z.), Leiden University Medical Centre; Department of Neurosurgery (L.A.W.), Maastricht University Medical Centre; and Department of Neurology (J.H.), Alrijne Hospital, Leiderdorp, the Netherlands. g.m.terwindt@lumc.nl.
Abstract
OBJECTIVE: As cluster headache (CH) is often referred to as "suicide headache," we wanted to assess the prevalence of depression in CH patients, and to investigate determinants of depression such as sleep disturbances. METHODS: In a cross-sectional, web-based, validated questionnaire study among 462 well-defined CH patients and 177 controls, we diagnosed CH according to the ICHD-III. We assessed depression using the Hospital Anxiety and Depression Scale (HADS-D) and the Center for Epidemiologic Studies Depression scale (CES-D) with supplementary questions to assess lifetime depression. Data were analyzed with logistic and linear regression models. RESULTS: Lifetime depression showed almost 3 times higher odds in CH patients (n = 462) than controls (n = 177) (odds ratio 2.77; 95% confidence interval 1.70-4.51). Chronic (n = 67) vs episodic (n = 394) patients had a higher prevalence of lifetime depression and more sleeping problems. Current depression was associated with having active attacks (last attack <1 month) (adjusted p = 0.02), but no effect remained after correction for sleep disturbances. CONCLUSIONS: CH is associated with an almost 3 times increased odds of lifetime depression. Current depression is highly prevalent in patients with active disease, in part related to sleep disturbances due to current nocturnal attacks.
OBJECTIVE: As cluster headache (CH) is often referred to as "suicide headache," we wanted to assess the prevalence of depression in CH patients, and to investigate determinants of depression such as sleep disturbances. METHODS: In a cross-sectional, web-based, validated questionnaire study among 462 well-defined CH patients and 177 controls, we diagnosed CH according to the ICHD-III. We assessed depression using the Hospital Anxiety and Depression Scale (HADS-D) and the Center for Epidemiologic Studies Depression scale (CES-D) with supplementary questions to assess lifetime depression. Data were analyzed with logistic and linear regression models. RESULTS:Lifetime depression showed almost 3 times higher odds in CH patients (n = 462) than controls (n = 177) (odds ratio 2.77; 95% confidence interval 1.70-4.51). Chronic (n = 67) vs episodic (n = 394) patients had a higher prevalence of lifetime depression and more sleeping problems. Current depression was associated with having active attacks (last attack <1 month) (adjusted p = 0.02), but no effect remained after correction for sleep disturbances. CONCLUSIONS: CH is associated with an almost 3 times increased odds of lifetime depression. Current depression is highly prevalent in patients with active disease, in part related to sleep disturbances due to current nocturnal attacks.
Authors: Amy S Grinberg; Rachel D Best; Kathryn M Min; Emmanuelle A D Schindler; Brian B Koo; Jason J Sico; Elizabeth K Seng Journal: Curr Pain Headache Rep Date: 2021-10-19
Authors: Matthew S Robbins; M Cristina C Victorio; Mark Bailey; Calli Cook; Ivan Garza; J Stephen Huff; Duren Ready; Nathaniel M Schuster; David Seidenwurm; Elizabeth Seng; Christina Szperka; Erin Lee; Raissa Villanueva Journal: Headache Date: 2020-09-23 Impact factor: 5.887
Authors: Matthew S Robbins; M Cristina Victorio; Mark Bailey; Calli Cook; Ivan Garza; J Stephen Huff; Duren Ready; M Schuster Nathaniel; David Seidenwurm; Elizabeth Seng; Christina Szperka; Erin Lee; Raissa Villanueva Journal: Neurology Date: 2020-09-23 Impact factor: 9.910