Jing Lu1, Guiying Mai1, Yan Luo1, Mei Li1, Di Cao1, Xiao Wang1, Hong Yan1, SriniVas R Sadda2, Lin Lu3. 1. State Key Laboratory of Ophthalmology, Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. 2. Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California. 3. State Key Laboratory of Ophthalmology, Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. Electronic address: drlulin@126.com.
Abstract
PURPOSE: To characterize the appearance of the far peripheral retina of normal eyes using ultra-widefield fluorescein angiography (UWFA). DESIGN: Cross-sectional study. METHODS: This study enrolled 101 eyes with best-corrected visual acuity ≥20/20, with refractive error <3.00 diopters, and without visible retinal pathologic changes under a slit lamp-based condensing lens. The far peripheral retina was detected by UWFA. Ciliary body thickness (CBT) at 3 mm (CBT1) and 2 mm (CBT2) posterior to the scleral spur was measured by ultrasound biomicroscopy. RESULTS: In the far peripheral retina, granular background fluorescence (GB) appeared in all eyes (100%), a mottled fluorescent band (MB) appeared in 44 eyes (43.6%), and retinal vascular leakage (VL) appeared in 20 eyes (19.8%). According to peripheral angiographic findings, the eyes were allocated into 3 groups: Group 1 (MB- and VL-), Group 2 (MB+ and VL-), and Group 3 (MB-/+ and VL+). Ultrasound biomicroscopy showed ciliary body edema and exudates in Group 3. The mean CBT1 (mm) and CBT2 (mm) of Group 3 were greater than those of Group 1 and Group 2 (0.315 ± 0.037 vs 0.240 ± 0.019 vs 0.251 ± 0.030; 0.571 ± 0.084 vs 0.375 ± 0.051 vs 0.410 ± 0.050, P < .001 for both CBT1 and CBT2). The mean CBT1 and CBT2 showed no difference between Group 1 and Group 2 (P = .575 for CBT1; P = .150 for CBT2). CONCLUSIONS: Normal peripheral retinas generally show granular background fluorescence, with or without a mottled fluorescent band. Copyright Â
PURPOSE: To characterize the appearance of the far peripheral retina of normal eyes using ultra-widefield fluorescein angiography (UWFA). DESIGN: Cross-sectional study. METHODS: This study enrolled 101 eyes with best-corrected visual acuity ≥20/20, with refractive error <3.00 diopters, and without visible retinal pathologic changes under a slit lamp-based condensing lens. The far peripheral retina was detected by UWFA. Ciliary body thickness (CBT) at 3 mm (CBT1) and 2 mm (CBT2) posterior to the scleral spur was measured by ultrasound biomicroscopy. RESULTS: In the far peripheral retina, granular background fluorescence (GB) appeared in all eyes (100%), a mottled fluorescent band (MB) appeared in 44 eyes (43.6%), and retinal vascular leakage (VL) appeared in 20 eyes (19.8%). According to peripheral angiographic findings, the eyes were allocated into 3 groups: Group 1 (MB- and VL-), Group 2 (MB+ and VL-), and Group 3 (MB-/+ and VL+). Ultrasound biomicroscopy showed ciliary body edema and exudates in Group 3. The mean CBT1 (mm) and CBT2 (mm) of Group 3 were greater than those of Group 1 and Group 2 (0.315 ± 0.037 vs 0.240 ± 0.019 vs 0.251 ± 0.030; 0.571 ± 0.084 vs 0.375 ± 0.051 vs 0.410 ± 0.050, P < .001 for both CBT1 and CBT2). The mean CBT1 and CBT2 showed no difference between Group 1 and Group 2 (P = .575 for CBT1; P = .150 for CBT2). CONCLUSIONS: Normal peripheral retinas generally show granular background fluorescence, with or without a mottled fluorescent band. Copyright Â
Authors: Karen W Jeng-Miller; Taha Soomro; Nathan L Scott; Prethy Rao; Elizabeth Marlow; Emmanuel Y Chang; Anna Ells; Felix Chau; Eric Nudleman; Charles M Calvo; Nish Patel; Roy Schwartz; Linda A Cernichiaro-Espinosa; Alexandrea Gabrielle Montoya; Jessica Goldstein; C Armitage Harper; Caroline R Baumal; Mary Elizabeth Hartnett; J William Harbour; Cagri G Besirli; Mrinali P Gupta; R V Paul Chan; Kimberly A Drenser; Antonio Capone; Timothy G Murray; Shizuo Mukai; Michael T Trese; Audina M Berrocal; Sui Chien Wong; Yoshihiro Yonekawa Journal: Ophthalmic Surg Lasers Imaging Retina Date: 2019-04-01 Impact factor: 1.300
Authors: Roy Schwartz; Sobha Sivaprasad; Rebecca Macphee; Patricia Ibanez; Pearse A Keane; Michel Michaelides; Sui Chien Wong Journal: Retina Date: 2019-12 Impact factor: 4.256
Authors: Jin Young Kim; Mi Young Choi; Eoi Jong Seo; Seungheon Lee; Ji Soo Kim; Ju Byung Chae; Dong Yoon Kim; June-Gone Kim Journal: Sci Rep Date: 2020-08-12 Impact factor: 4.379