| Literature DB >> 27693431 |
Harshali Patil1, Shailaja Gada Saxena2, Colin J Barrow3, Jagat R Kanwar4, Arnab Kapat5, Rupinder K Kanwar6.
Abstract
Colorectal cancer (CRC) is a major health burden worldwide. The optimal approach to the diagnosis, management, and treatment of CRC involves multidisciplinary and integrated management practices. The field is rapidly changing because of recent advancements in delineating the molecular basis of tumorigenesis, introduction of targeted therapy, varied patient response to mainstay chemotherapeutics, biological drugs, and the effective combination regimes being used for treatment. Recent meta-analysis studies, which tend to establish few clinically useful predictor biomarkers, identify inconsistent results and limitations of the trials. Therefore, molecular pathological epidemiology discipline initiatives are promising. Here, we provide an overview of the potential of biomarker validation for personalized medicine by focusing largely on metastatic (m)CRC. We also highlight new candidate predictive and prognostic biomarkers.Entities:
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Year: 2016 PMID： 27693431 DOI： 10.1016/j.drudis.2016.09.022
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851