Yujiro Kose1, Masahiro Ikenaga2, Yosuke Yamada3, Kazuhiro Morimura4, Noriko Takeda5, Shinji Ouma6, Yoshio Tsuboi6, Tatsuo Yamada7, Misaka Kimura8, Akira Kiyonaga9, Yasuki Higaki10, Hiroaki Tanaka9. 1. Graduate School of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. 2. Faculty of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. 3. Department of Nutritional Science, National Institutes of Biomedical Innovation, Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan. 4. Department of Education, Syujitsu University, 1-6-1 Nishi-kawahara, Naka-ku, Okayama, 703-8516, Japan. 5. Kogakuin University, Division of Liberal Arts, 2665-1 Nakano, Hachioji, Tokyo 192-0015, Japan. 6. Department of Neurology, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. 7. Department of Neurology, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan; Gotanda Rehabilitation Hospital, 8-8-20 Nishi-gotanda, Shinagawa-ku, Tokyo 141-0031, Japan. 8. Faculty of Health and Medical Sciences, Kyoto Gakuen University, 1-1 Nanjyo-Otani, Sokabemachi, Kameoka, Kyoto 621-8555, Japan; The Fukuoka University Institute for Physical Activity, Fukuoka University, Fukuoka, Japan. 9. Faculty of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan; The Fukuoka University Institute for Physical Activity, Fukuoka University, Fukuoka, Japan. 10. Faculty of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan; The Fukuoka University Institute for Physical Activity, Fukuoka University, Fukuoka, Japan. Electronic address: higaki@fukuoka-u.ac.jp.
Abstract
AIM: This study aimed to ascertain if performance on the Timed Up and Go (TUG) test is associated with indicators of brain volume and cognitive functions among community-dwelling older adults with normal cognition or mild cognitive impairment. METHODS: Participants were 80 community-dwelling older adults aged 65-89years (44 men, 36 women), including 20 with mild cognitive impairment. Participants completed the TUG and a battery of cognitive assessments, including the Mini-Mental State Examination (MMSE), the Logical Memory I and II (LM-I, LM-II) subtests of the Wechsler Memory Scale-Revised; and the Trail Making Test A and B (TMT-A, TMT-B). Bilateral, right- and left-side medial temporal area atrophy as well as whole gray and white matter indices were determined with the Voxel-based Specific Regional Analysis System for Alzheimer's Disease. We divided participants into three groups based on TUG performance: "better" (≤6.9s); "normal" (7-10s); and "poor" (≥10.1s). RESULTS: Worse TMT-A and TMT-B performance showed significant independent associations with worse TUG performance (P<0.05, P<0.01 for trend, respectively). After adjusting for covariates, severe atrophy of bilateral, right-, and left-side medial temporal areas were significantly independently associated with worse TUG performance (P<0.05 for trend). However, no significant associations were found between MMSE, LM-I, LM-II, whole gray and white matter indices, and TUG performance. CONCLUSIONS: Worse TUG performance is related to poor performance on TMT-A and TMT-B, and is independently associated with severe medial temporal area atrophy in community-dwelling older adults.
AIM: This study aimed to ascertain if performance on the Timed Up and Go (TUG) test is associated with indicators of brain volume and cognitive functions among community-dwelling older adults with normal cognition or mild cognitive impairment. METHODS:Participants were 80 community-dwelling older adults aged 65-89years (44 men, 36 women), including 20 with mild cognitive impairment. Participants completed the TUG and a battery of cognitive assessments, including the Mini-Mental State Examination (MMSE), the Logical Memory I and II (LM-I, LM-II) subtests of the Wechsler Memory Scale-Revised; and the Trail Making Test A and B (TMT-A, TMT-B). Bilateral, right- and left-side medial temporal area atrophy as well as whole gray and white matter indices were determined with the Voxel-based Specific Regional Analysis System for Alzheimer's Disease. We divided participants into three groups based on TUG performance: "better" (≤6.9s); "normal" (7-10s); and "poor" (≥10.1s). RESULTS: Worse TMT-A and TMT-B performance showed significant independent associations with worse TUG performance (P<0.05, P<0.01 for trend, respectively). After adjusting for covariates, severe atrophy of bilateral, right-, and left-side medial temporal areas were significantly independently associated with worse TUG performance (P<0.05 for trend). However, no significant associations were found between MMSE, LM-I, LM-II, whole gray and white matter indices, and TUG performance. CONCLUSIONS: Worse TUG performance is related to poor performance on TMT-A and TMT-B, and is independently associated with severe medial temporal area atrophy in community-dwelling older adults.
Authors: Andrea L Rosso; Joe Verghese; Andrea L Metti; Robert M Boudreau; Howard J Aizenstein; Stephen Kritchevsky; Tamara Harris; Kristine Yaffe; Suzanne Satterfield; Stephanie Studenski; Caterina Rosano Journal: Neurology Date: 2017-06-28 Impact factor: 9.910
Authors: Maria H Nilsson; Gro Gujord Tangen; Sebastian Palmqvist; Danielle van Westen; Niklas Mattsson-Carlgren; Erik Stomrud; Oskar Hansson Journal: J Gerontol A Biol Sci Med Sci Date: 2021-03-31 Impact factor: 6.053