Eunice Song1, Jane M Grant-Kels2, Helen Swede3, Jody L D'Antonio4, Avery Lachance5, Soheil S Dadras4, Arni K Kristjansson4, Katalin Ferenczi4, Hanspaul S Makkar4, Marti J Rothe4. 1. University of Connecticut School of Medicine, Farmington, Connecticut. 2. Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut. Electronic address: grant@uchc.edu. 3. Department of Community Medicine and Health Care, University of Connecticut Health Center, Farmington, Connecticut; University of Connecticut School of Medicine, Farmington, Connecticut. 4. Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut. 5. Department of Dermatology, Harvard Medical School, Boston, Massachusetts.
Abstract
BACKGROUND: Several technologies have been developed to aid dermatologists in the detection of melanoma in vivo including dermoscopy, multispectral digital skin lesion analysis (MDSLA), and reflectance confocal microscopy (RCM). To our knowledge, there have been no studies directly comparing MDSLA and RCM. OBJECTIVE: We conducted a repeated measures analysis comparing the sensitivity and specificity of MDSLA and RCM in the detection of melanoma (n = 55 lesions from 36 patients). METHODS: Study patients (n = 36) with atypical-appearing pigmented lesions (n = 55) underwent imaging by both RCM and MDSLA. Lesions were biopsied and analyzed by histopathology. RESULTS: RCM exhibited superior test metrics (P = .001, McNemar test) compared with MDSLA. Respectively, sensitivity measures were 85.7% and 71.4%, and specificity rates were 66.7% and 25.0%. LIMITATIONS: The sample size was relatively small and was collected from only one dermatologist's patient base; there was some degree of dermatopathologist interobserver variability; and only one confocalist performed the RCM image evaluations. CONCLUSION: RCM is a useful adjunct during clinical assessment of in vivo lesions suspicious for melanoma or those requiring re-excision because of high level of dysplasia or having features consistent with an atypical melanocytic nevus with severe cytologic atypia.
BACKGROUND: Several technologies have been developed to aid dermatologists in the detection of melanoma in vivo including dermoscopy, multispectral digital skin lesion analysis (MDSLA), and reflectance confocal microscopy (RCM). To our knowledge, there have been no studies directly comparing MDSLA and RCM. OBJECTIVE: We conducted a repeated measures analysis comparing the sensitivity and specificity of MDSLA and RCM in the detection of melanoma (n = 55 lesions from 36 patients). METHODS: Study patients (n = 36) with atypical-appearing pigmented lesions (n = 55) underwent imaging by both RCM and MDSLA. Lesions were biopsied and analyzed by histopathology. RESULTS:RCM exhibited superior test metrics (P = .001, McNemar test) compared with MDSLA. Respectively, sensitivity measures were 85.7% and 71.4%, and specificity rates were 66.7% and 25.0%. LIMITATIONS: The sample size was relatively small and was collected from only one dermatologist's patient base; there was some degree of dermatopathologist interobserver variability; and only one confocalist performed the RCM image evaluations. CONCLUSION:RCM is a useful adjunct during clinical assessment of in vivo lesions suspicious for melanoma or those requiring re-excision because of high level of dysplasia or having features consistent with an atypical melanocytic nevus with severe cytologic atypia.
Authors: A M Witkowski; J Łudzik; F Arginelli; S Bassoli; E Benati; A Casari; N De Carvalho; B De Pace; F Farnetani; A Losi; M Manfredini; C Reggiani; J Malvehy; G Pellacani Journal: PLoS One Date: 2017-11-09 Impact factor: 3.240
Authors: Stig Uteng; Eduardo Quevedo; Gustavo M Callico; Irene Castaño; Gregorio Carretero; Pablo Almeida; Aday Garcia; Javier A Hernandez; Fred Godtliebsen Journal: Sensors (Basel) Date: 2021-01-20 Impact factor: 3.576