Morphological and physiological properties of neurons after long-term axonal regeneration: observations on chronic and delayed sequelae of peripheral nerve injury.

Axonal regeneration has been the focus of extensive investigation of mechanisms which mediate structural and functional recovery after injury to mammalian peripheral nerves and has proven to be a valuable model for development and plasticity in the nervous system. Although details of the acute morphological and physiological responses to nerve injury are well-described, less information is available to nerve injury are well-described, less information is available about long-term alterations which persist or develop after regenerated axons have established connections with their targets. The present paper briefly discusses the mammalian neuron's initial response to peripheral nerve injury and subsequent events which occur during regeneration. Morphological and physiological alterations observed in neurons after long-term axonal regeneration are described and are considered in the context of their potential implications for clinical recovery after nerve injury, as well as their potential contribution to the appearance of delayed neurological dysfunction. Selective responses to neuronal injury during development and in different fiber populations are discussed.