Literature DB >> 27692094

Macrophage effector responses of horses are influenced by expression of CD154.

Brett A Sponseller1, Sandra K Clark2, Jessica Gilbertie3, David M Wong4, Kate Hepworth5, Sarah Wiechert6, Prashanth Chandramani7, Beatrice T Sponseller8, Cody J Alcott9, Bryan Bellaire10, Andrew C Petersen11, Douglas E Jones12.   

Abstract

Reactive intermediates contribute to innate immunity by providing phagocytes with a mechanism of defense against bacteria, viruses and parasites. To better characterize the role of CD154 in the production of reactive intermediates, we cloned and expressed recombinant equine CD154 (reqCD154) in Chinese Hamster Ovary (CHO). In co-culture experiments, CHO cells ectopically expressing reqCD154 elicited superoxide production in monocyte-derived macrophages (MDM). Collectively, our results indicate that regulation of CD154 expression plays a role in innate host defenses.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  CD154; Equine; Reactive intermediates

Mesh：

Substances：

Year:  2016        PMID： 27692094      PMCID： PMC7043372          DOI： 10.1016/j.vetimm.2016.08.001

Source DB:  PubMed          Journal:  Vet Immunol Immunopathol        ISSN： 0165-2427            Impact factor:   2.046


  25 in total

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2.  CD154 Expression Indicates T Cell Activation Following Tetanus Toxoid Vaccination of Horses.

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