| Literature DB >> 27690628 |
Qu-Tong Zheng1,2, Ze-Hua Yang1,2, Liu-Ying Yu1,2, Yu-Yan Ren1,2, Qiu-Xia Huang1,2, Qiu Liu1,2,3, Xiang-Yu Ma1,2, Zi-Kang Chen1,2,3, Zong-Bao Wang1,2, Xing Zheng1,2.
Abstract
Numerous biological activities including antioxidant, antitumor, anti-inflammation, and antivirus of the natural product curcumin were reported. However, the clinical application of it was significantly limited by its instability, poor solubility, less body absorbing, and low bioavailability. This review focuses on the structure modification and antioxidant activity evaluation of curcumin. To study the structure-activity relationship (SAR), five series of curcumin analogs were synthesized and their antioxidant activity were evaluated in vitro. The results showed that electron-donating groups, especially the phenolic hydroxyl group are an essential component to improve the antioxidant activity.Entities:
Keywords: Curcumin; antioxidant activity; structure modification; structure–activity relationship
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Year: 2016 PMID： 27690628 DOI： 10.1080/10286020.2016.1235562
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569