Ceyla Erhan1, Gresa Çarkaxhiu Bulut2, Sebla Gökçe3, Duru Ozbas1, Esin Turkakin1, Onur Burak Dursun4, Yanki Yazgan5, Fuat Balcı6. 1. Department of Psychology, Koç University, İstanbul, Turkey. 2. Child and Adolescent Psychiatry, Muş State Hospital, Muş, Turkey. 3. Child and Adolescent Psychiatry, Maltepe University, İstanbul, Turkey. 4. Child and Adolescent Psychiatry, Atatürk University, Erzurum, Turkey. 5. Department of Child Psychiatry, Marmara University Faculty of Medicine, İstanbul, Turkey; Child Study Center, Yale University School of Medicine, New Haven, CT, USA. 6. Department of Psychology, Koç University, İstanbul, Turkey. Electronic address: fbalci@ku.edu.tr.
Abstract
BACKGROUND: Decision-making in Obsessive Compulsive Disorder has typically been investigated in the adult population. Computational approaches have recently started to get integrated into these studies. However, decision-making research in pediatric OCD populations is scarce. METHODS: We investigated latent decision processes in 21 medication-free pediatric OCD patients and 23 healthy control participants. We hypothesized that OCD patients would be more cautious and less efficient in evidence accumulation than controls in a two alternative forced choice (2AFC) task. RESULTS: Pediatric OCD patients were less efficient than controls in accumulating perceptual evidence and showed a tendency to be more cautious. In comparison to post-correct decisions, OCD patients increased decision thresholds after erroneous decisions, whereas healthy controls decreased decision thresholds. These changes were coupled with weaker evidence accumulation after errors in both groups. LIMITATIONS: The small sample size limited the power of the study. CONCLUSIONS: Our results demonstrate poorer decision-making performance in pediatric OCD patients at the level of latent processes, specifically in terms of evidence accumulation.
BACKGROUND: Decision-making in Obsessive Compulsive Disorder has typically been investigated in the adult population. Computational approaches have recently started to get integrated into these studies. However, decision-making research in pediatric OCD populations is scarce. METHODS: We investigated latent decision processes in 21 medication-free pediatric OCDpatients and 23 healthy control participants. We hypothesized that OCDpatients would be more cautious and less efficient in evidence accumulation than controls in a two alternative forced choice (2AFC) task. RESULTS: Pediatric OCDpatients were less efficient than controls in accumulating perceptual evidence and showed a tendency to be more cautious. In comparison to post-correct decisions, OCDpatients increased decision thresholds after erroneous decisions, whereas healthy controls decreased decision thresholds. These changes were coupled with weaker evidence accumulation after errors in both groups. LIMITATIONS: The small sample size limited the power of the study. CONCLUSIONS: Our results demonstrate poorer decision-making performance in pediatric OCDpatients at the level of latent processes, specifically in terms of evidence accumulation.
Authors: Aleya A Marzuki; Ivan Tomic; Samantha Hiu Yan Ip; Julia Gottwald; Jonathan W Kanen; Muzaffer Kaser; Akeem Sule; Anna Conway-Morris; Barbara J Sahakian; Trevor W Robbins Journal: JAMA Netw Open Date: 2021-11-01