Chia-Ter Chao1,2,3, Chih-Kang Chiang3,4. 1. Department of Medicine, National Taiwan University Hospital Jinshan Branch, New Taipei City, Taiwan. 2. Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan. 3. Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. 4. Department of Integrative Diagnostics and Therapeutics, National Taiwan University Hospital, Taipei, Taiwan.