Literature DB >> 27688567

Use of Anti-Craving Agents in Soldiers with Alcohol Dependence Syndrome.

P L Narayana1, A K Gupta2, P K Sharma3.   

Abstract

BACKGROUND: In a search for an effective 'anti-alcohol pill', three modern anti-craving agents have been studied in alcoholics of Army/ DSC, Air Force, Navy and Coast Guard.
METHODS: 129 patients of alcohol dependence syndrome were randomly assigned to three groups where topiramate, acamprosate and naltrexone were used as anti-craving agents in a year long prospective study. Of these 92 patients completed the study. RESULT AND
CONCLUSION: Topiramate (76.3%) appears to be significantly more effective (p<0.01) in sustaining abstinence, though naltrexone (57.7%) and acamprosate (60.70%) offer moderate relapse-prevention efficacy. Side effects of all the three agents have been mild, transient and self-limiting. We recommend a trial of topiramate, before invaliding out of any alcoholic soldier.

Entities:  

Keywords:  Acamprosate; Alcohol dependence syndrome; Naltrexone; Topiramate

Year:  2011        PMID： 27688567      PMCID： PMC5035271          DOI： 10.1016/S0377-1237(08)80009-3

Source DB:  PubMed          Journal:  Med J Armed Forces India        ISSN： 0377-1237


  20 in total

1.  Topiramate for the treatment of alcohol dependence: initiating abstinence.

Authors:  Robert M Swift
Journal:  Lancet       Date:  2003-05-17       Impact factor: 79.321

Review 2.  An overview of the development of medications including novel anticonvulsants for the treatment of alcohol dependence.

Authors:  Bankole A Johnson
Journal:  Expert Opin Pharmacother       Date:  2004-09       Impact factor: 3.889

3.  Lack of efficacy of naltrexone in the prevention of alcohol relapse: results from a German multicenter study.

Authors:  Markus Gastpar; Udo Bonnet; Jobst Böning; Karl Mann; Lutz G Schmidt; Michael Soyka; Tilman Wetterling; Volker Kielstein; Dominic Labriola; Robert Croop
Journal:  J Clin Psychopharmacol       Date:  2002-12       Impact factor: 3.153

Review 4.  Pharmacotherapy, pharmacogenomics, and the future of alcohol dependence treatment, part 1.

Authors:  George A Kenna; John E McGeary; Robert M Swift
Journal:  Am J Health Syst Pharm       Date:  2004-11-01       Impact factor: 2.637

Review 5.  Progress in the development of topiramate for treating alcohol dependence: from a hypothesis to a proof-of-concept study.

Authors:  Bankole A Johnson
Journal:  Alcohol Clin Exp Res       Date:  2004-08       Impact factor: 3.455

Review 6.  Recent advances in the pharmacotherapy of alcoholism.

Authors:  Hugh Myrick; Raymond Anton
Journal:  Curr Psychiatry Rep       Date:  2004-10       Impact factor: 5.285

7.  Initial and maintenance naltrexone treatment for alcohol dependence using primary care vs specialty care: a nested sequence of 3 randomized trials.

Authors:  Stephanie S O'Malley; Bruce J Rounsaville; Conor Farren; Kee Namkoong; Ran Wu; Jane Robinson; Patrick G O'Connor
Journal:  Arch Intern Med       Date:  2003-07-28

8.  Oral topiramate for treatment of alcohol dependence: a randomised controlled trial.

Authors:  Bankole A Johnson; Nassima Ait-Daoud; Charles L Bowden; Carlo C DiClemente; John D Roache; Kevin Lawson; Martin A Javors; Jennie Z Ma
Journal:  Lancet       Date:  2003-05-17       Impact factor: 79.321

9.  A clinical laboratory paradigm for evaluating medication effects on alcohol consumption: naltrexone and nalmefene.

Authors:  David J Drobes; Raymond F Anton; Suzanne E Thomas; Konstantin Voronin
Journal:  Neuropsychopharmacology       Date:  2002-10-30       Impact factor: 7.853

Review 10.  Pharmacotherapy for alcohol dependence: anticraving medications for relapse prevention.

Authors:  Young-Chul Jung; Kee Namkoong
Journal:  Yonsei Med J       Date:  2006-04-30       Impact factor: 2.759
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  2 in total

Review 1.  Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse.

Authors:  C E Van Skike; S E Maggio; A R Reynolds; E M Casey; M T Bardo; L P Dwoskin; M A Prendergast; K Nixon
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2015-11-12       Impact factor: 5.067

2.  Relationship between Craving and Early Relapse in Alcohol Dependence: A Short-Term Follow-up Study.

Authors:  Rajan Kharb; Lokesh S Shekhawat; Ram Pratap Beniwal; Triptish Bhatia; Smita N Deshpande
Journal:  Indian J Psychol Med       Date:  2018 Jul-Aug
  2 in total

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