K Chand1, R Khandelwal2, V Vardhan3. 1. ADMS, HQ 5 Mountain Division, C/o 99 APO. 2. Classified Specialist (Pathology), Military Hospital, Kirkee. 3. Classified Specialist (Medicine & Respiratory diseases), Military Hospital (CTC), Pune-40.
Abstract
BACKGROUND: Incidence of drug resistance and pattern of susceptibility to antitubercular drugs in pulmonary tuberculosis amongst soldiers and their families was studied for four years at a military hospital in northwest India. METHODS: Identification and susceptibility tests were carried out as per procedures laid out in laboratory manual of Tuberculosis Research Centre (TRC), Chennai. RESULTS: Of the 172 strains of Mycobacterium tuberculosis (MTB) isolated from sputum samples, 150 (87.21%) were sensitive and 22 (12.79%) showed resistance to one or more antitubercular drugs. Acquired drug resistance was observed in 7 (31.82%) and primary drug resistance in 15 (68.18%) cases. Among 22 drug resistant cases, who were on short course chemotherapy (SCC), resistance to single drug was observed in 12 (54.54%), two drugs in 7 (31.82%) and to three or more drugs in 3 (13.64%) isolates. Fourteen (18.14%) strains were resistant to Streptomycin, 8 (4.65%) to Rifampicin, 11 (6.40%) to Isoniazid, 1 (0.58%) to Pyrazinamide and 2 (1.16%) to Ethambutol. Multidrug resistance was observed in 5 (2.91%) cases, of which resistance to Isoniazid and Rifampicin was present in 2 (1.16%) and their combination with other drugs in other 3 (1.74%) isolates. CONCLUSIONS: Drug susceptibility pattern to antitubercular drugs is discussed and compared with studies from other centres.
BACKGROUND: Incidence of drug resistance and pattern of susceptibility to antitubercular drugs in pulmonary tuberculosis amongst soldiers and their families was studied for four years at a military hospital in northwest India. METHODS: Identification and susceptibility tests were carried out as per procedures laid out in laboratory manual of Tuberculosis Research Centre (TRC), Chennai. RESULTS: Of the 172 strains of Mycobacterium tuberculosis (MTB) isolated from sputum samples, 150 (87.21%) were sensitive and 22 (12.79%) showed resistance to one or more antitubercular drugs. Acquired drug resistance was observed in 7 (31.82%) and primary drug resistance in 15 (68.18%) cases. Among 22 drug resistant cases, who were on short course chemotherapy (SCC), resistance to single drug was observed in 12 (54.54%), two drugs in 7 (31.82%) and to three or more drugs in 3 (13.64%) isolates. Fourteen (18.14%) strains were resistant to Streptomycin, 8 (4.65%) to Rifampicin, 11 (6.40%) to Isoniazid, 1 (0.58%) to Pyrazinamide and 2 (1.16%) to Ethambutol. Multidrug resistance was observed in 5 (2.91%) cases, of which resistance to Isoniazid and Rifampicin was present in 2 (1.16%) and their combination with other drugs in other 3 (1.74%) isolates. CONCLUSIONS: Drug susceptibility pattern to antitubercular drugs is discussed and compared with studies from other centres.
Entities:
Keywords:
Antitubercular drugs; Drug resistance; Mycobacterium tuberculosis
Authors: P M Small; R W Shafer; P C Hopewell; S P Singh; M J Murphy; E Desmond; M F Sierra; G K Schoolnik Journal: N Engl J Med Date: 1993-04-22 Impact factor: 91.245
Authors: B Malhotra; S Pathak; L Vyas; V M Katoch; K Srivastava; D S Chauhan; D Singh; V D Sharma; R Das; H B Singh Journal: Indian J Med Microbiol Date: 2002 Apr-Jun Impact factor: 0.985
Authors: C Beck-Sagué; S W Dooley; M D Hutton; J Otten; A Breeden; J T Crawford; A E Pitchenik; C Woodley; G Cauthen; W R Jarvis Journal: JAMA Date: 1992-09-09 Impact factor: 56.272