Literature DB >> 27688182

4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation.

Amandeep Singh1, Jiri Gut2, Philip J Rosenthal2, Vipan Kumar3.   

Abstract

A series of aliphatic and aromatic substituted 1H-1,2,3-triazole-tethered 4-amino-quinoline-ferrocenylchalcone conjugates has been synthesized and evaluated for anti-plasmodial activity. The conjugates with flexible aliphatic (aminoethanol or aminopropanol) substituents on the quinoline ring showed better anti-plasmodial activities compared to those with cyclic (piperazine or aminophenol) substituents. The conjugate 17j was the most potent and non-cytotoxic, with an IC50 value of 0.37 μM against the chloroquine-resistant W2 strain of Plasmodium falciparum. Copyright Â
© 2016 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  1,3-dipolar cycloaddition; 4-Amino-quinoline-ferrocenylchalcone; Antiplasmodial activities; Structure-activity relationship

Mesh：

Substances：

Year:  2016        PMID： 27688182     DOI： 10.1016/j.ejmech.2016.09.044

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  11 in total

1.  Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights.

Authors:  Jenny Legac; Adebayo A Adeniyi; Prishani Kisten; Philip J Rosenthal; Parvesh Singh; Vipan Kumar
Journal:  ACS Med Chem Lett       Date:  2020-01-08       Impact factor: 4.345

Review 2.  Quinoline-Based Hybrid Compounds with Antimalarial Activity.

Authors:  Xhamla Nqoro; Naki Tobeka; Blessing A Aderibigbe
Journal:  Molecules       Date:  2017-12-19       Impact factor: 4.411

3.  Azide-Alkyne Cycloaddition En Route to 1H-1,2,3-Triazole-Tethered Isatin-Ferrocene, Ferrocenylmethoxy-Isatin, and Isatin-Ferrocenylchalcone Conjugates: Synthesis and Antiproliferative Evaluation.

Authors:  Amandeep Singh; Sourav Taru Saha; Shanen Perumal; Mandeep Kaur; Vipan Kumar
Journal:  ACS Omega       Date:  2018-01-30

4.  Synthesis and Preliminary Antimicrobial Analysis of Isatin-Ferrocene and Isatin-Ferrocenyl Chalcone Conjugates.

Authors:  Amandeep Singh; Grant Fong; Jenny Liu; Yun-Hsuan Wu; Kevin Chang; William Park; Jihwan Kim; Christina Tam; Luisa W Cheng; Kirkwood M Land; Vipan Kumar
Journal:  ACS Omega       Date:  2018-05-30

5.  Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials.

Authors:  Anu Rani; Sumit Kumar; Jenny Legac; Adebayo A Adeniyi; Paul Awolade; Parvesh Singh; Philip J Rosenthal; Vipan Kumar
Journal:  Future Med Chem       Date:  2019-12-05       Impact factor: 3.808

Review 6.  Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry.

Authors:  Daniela Pereira; Madalena Pinto; Marta Correia-da-Silva; Honorina Cidade
Journal:  Molecules       Date:  2021-12-30       Impact factor: 4.411

7.  Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers.

Authors:  Anu Rani; Albertus Viljoen; Matt D Johansen; Laurent Kremer; Vipan Kumar
Journal:  RSC Adv       Date:  2019-03-13       Impact factor: 4.036

Review 8.  Quinoline derivatives volunteering against antimicrobial resistance: rational approaches, design strategies, structure activity relationship and mechanistic insights.

Authors:  Nitish Kumar; Aanchal Khanna; Komalpreet Kaur; Harmandeep Kaur; Anchal Sharma; Preet Mohinder Singh Bedi
Journal:  Mol Divers       Date:  2022-10-05       Impact factor: 3.364

9.  Design, Synthesis and Preliminary Antimicrobial Evaluation of N-Alkyl Chain Tethered C-5 Functionalized Bis-Isatins.

Authors:  Amandeep Singh; Trpta Bains; Hye Jee Hahn; Nicole Liu; Christina Tam; Luisa W Cheng; Jong Kim; Anjan Debnath; Kirkwood M Land; Vipan Kumar
Journal:  Medchemcomm       Date:  2017-09-19       Impact factor: 3.597

Review 10.  Recent Advances in the Discovery of Novel Antiprotozoal Agents.

Authors:  Seong-Min Lee; Min-Sun Kim; Faisal Hayat; Dongyun Shin
Journal:  Molecules       Date:  2019-10-28       Impact factor: 4.411
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