Mitana Purkayastha1, Alex D McMahon2, John Gibson3, David I Conway4. 1. School of Medicine, Dentistry and Nursing, University of Glasgow, 378 Sauchiehall Street, Glasgow G2 3JZ, United Kingdom. Electronic address: m.purkayastha.1@research.gla.ac.uk. 2. School of Medicine, Dentistry and Nursing, University of Glasgow, 378 Sauchiehall Street, Glasgow G2 3JZ, United Kingdom. Electronic address: Alex.McMahon@glasgow.ac.uk. 3. School of Medicine, Dentistry and Nursing, University of Glasgow, 378 Sauchiehall Street, Glasgow G2 3JZ, United Kingdom. Electronic address: John.Gibson.2@glasgow.ac.uk. 4. School of Medicine, Dentistry and Nursing, University of Glasgow, 378 Sauchiehall Street, Glasgow G2 3JZ, United Kingdom. Electronic address: David.Conway@glasgow.ac.uk.
Abstract
AIM: To examine current incidence trends (1975-2012) of oral cavity (OCC), oropharyngeal (OPC) and laryngeal cancer in Scotland by socioeconomic status (SES). METHODS: We included all diagnosed cases of OCC (C00.3-C00.9, C02-C06 excluding C2.4), OPC (C01, C2.4, C09-C10, C14) and laryngeal cancer (C32) on the Scottish Cancer Registry (1975-2012) and annual midterm population estimates by age, sex, geographic region and SES indices (Carstairs 1991 and Scottish Index of Multiple Deprivation 2009). Age-standardized incidence rates were computed and adjusted Poisson regression rate-ratios (RR) compared subsites by age, sex, region, SES and year of diagnosis. RESULTS: We found 28,217 individuals (19,755 males and 8462 females) diagnosed with head and neck cancer (HNC) over the study period. Between 1975 and 2012, relative to the least deprived areas, those living in the most deprived areas exhibited the highest RR (>double) of OCC, OPC and laryngeal cancer, and an almost dose-like response was observed between SES and HNC incidence. Between 2001 and 2012, this socioeconomic inequality tended to increase over time for OPC and laryngeal cancer but remained relatively unchanged for OCC. Incidence rates increased markedly for OPC, decreased for laryngeal cancer and remained stable for OCC, particularly in the last decade. Males exhibited significantly higher RRs compared to females, and the peak age of incidence of OPC was slightly lower than the other subsites. CONCLUSION: Contrary to reports that OPC exhibits an inverse socioeconomic profile, Scotland country-level data show that those from the most deprived areas consistently have the highest rates of head and neck cancers.
AIM: To examine current incidence trends (1975-2012) of oral cavity (OCC), oropharyngeal (OPC) and laryngeal cancer in Scotland by socioeconomic status (SES). METHODS: We included all diagnosed cases of OCC (C00.3-C00.9, C02-C06 excluding C2.4), OPC (C01, C2.4, C09-C10, C14) and laryngeal cancer (C32) on the Scottish Cancer Registry (1975-2012) and annual midterm population estimates by age, sex, geographic region and SES indices (Carstairs 1991 and Scottish Index of Multiple Deprivation 2009). Age-standardized incidence rates were computed and adjusted Poisson regression rate-ratios (RR) compared subsites by age, sex, region, SES and year of diagnosis. RESULTS: We found 28,217 individuals (19,755 males and 8462 females) diagnosed with head and neck cancer (HNC) over the study period. Between 1975 and 2012, relative to the least deprived areas, those living in the most deprived areas exhibited the highest RR (>double) of OCC, OPC and laryngeal cancer, and an almost dose-like response was observed between SES and HNC incidence. Between 2001 and 2012, this socioeconomic inequality tended to increase over time for OPC and laryngeal cancer but remained relatively unchanged for OCC. Incidence rates increased markedly for OPC, decreased for laryngeal cancer and remained stable for OCC, particularly in the last decade. Males exhibited significantly higher RRs compared to females, and the peak age of incidence of OPC was slightly lower than the other subsites. CONCLUSION: Contrary to reports that OPC exhibits an inverse socioeconomic profile, Scotland country-level data show that those from the most deprived areas consistently have the highest rates of head and neck cancers.
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Authors: David I Conway; Jan Hovanec; Wolfgang Ahrens; Alastair Ross; Ivana Holcatova; Pagona Lagiou; Diego Serraino; Cristina Canova; Lorenzo Richiardi; Claire Healy; Kristina Kjaerheim; Gary J Macfarlane; Peter Thomson; Antonio Agudo; Ariana Znaor; Paul Brennan; Danièle Luce; Gwenn Menvielle; Isabelle Stucker; Simone Benhamou; Heribert Ramroth; Paolo Boffetta; Marta Vilensky; Leticia Fernandez; Maria Paula Curado; Ana Menezes; Alexander Daudt; Rosalina Koifman; Victor Wunsch-Filho; Amy Lee Yuan-Chin; Mia Hashibe; Thomas Behrens; Alex D McMahon Journal: J Epidemiol Community Health Date: 2021-02-23 Impact factor: 3.710