Jason Langley1,2, Daniel E Huddleston3, Christine J Liu4, Xiaoping Hu5,6. 1. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. 2. Center for Advanced Neuroimaging, University of California, Riverside, Riverside, CA, USA. 3. Department of Neurology, Emory University, Atlanta, GA, USA. 4. The Westminster Schools, Atlanta, GA, USA. 5. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. xhu@engr.ucr.edu. 6. Department of Bioengineering, University of California, Riverside, Materials Science and Engineering 205, Riverside, CA, USA. xhu@engr.ucr.edu.
Abstract
OBJECTIVES: The purpose of this study was to assess the reproducibility of substantia nigra pars compacta (SNpc) and locus coeruleus (LC) delineation and measurement with neuromelanin-sensitive MRI. MATERIALS AND METHODS: Eleven subjects underwent two neuromelanin-sensitive MRI scans. SNpc and LC volumes were extracted for each scan. Reproducibility of volume and magnetization transfer contrast measurements in SNpc and LC was assessed using intraclass correlation coefficients (ICC) and dice similarity coefficients (DSC). RESULTS: SNpc and LC volume measurements showed excellent reproducibility (SNpc-ICC: 0.94, p < 0.001; LC-ICC: 0.96, p < 0.001). SNpc and LC were accurately delineated between scans (SNpc-DSC: 0.80 ± 0.03; LC-DSC: 0.63 ± 0.07). CONCLUSION: Neuromelanin-sensitive MRI can consistently delineate SNpc and LC.
OBJECTIVES: The purpose of this study was to assess the reproducibility of substantia nigra pars compacta (SNpc) and locus coeruleus (LC) delineation and measurement with neuromelanin-sensitive MRI. MATERIALS AND METHODS: Eleven subjects underwent two neuromelanin-sensitive MRI scans. SNpc and LC volumes were extracted for each scan. Reproducibility of volume and magnetization transfer contrast measurements in SNpc and LC was assessed using intraclass correlation coefficients (ICC) and dice similarity coefficients (DSC). RESULTS: SNpc and LC volume measurements showed excellent reproducibility (SNpc-ICC: 0.94, p < 0.001; LC-ICC: 0.96, p < 0.001). SNpc and LC were accurately delineated between scans (SNpc-DSC: 0.80 ± 0.03; LC-DSC: 0.63 ± 0.07). CONCLUSION:Neuromelanin-sensitive MRI can consistently delineate SNpc and LC.
Entities:
Keywords:
Locus coeruleus; Magnetic resonance imaging; Neuromelanin; Reproducibility; Substantia nigra
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