Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Nuf and Rip11 requirement for polarity determinant recycling during Drosophila development.

Literature DB >> 27687567

Nuf and Rip11 requirement for polarity determinant recycling during Drosophila development.

Francisco J Calero-Cuenca¹, Sol Sotillos¹.

Abstract

A tight relationship between apico-basal polarity and trafficking is essential for epithelial physiology and tissue homeostasis. Recent studies have described how some Rab GTPases, key components of the intracellular traffic machinery, contribute to the establishment of cell polarity in vertebrates. We have demonstrated a novel connection between cell polarity and trafficking: in Drosophila epithelia, the apical determinant aPKC is recycled via Rab11-Nuf-recycling endosomes to maintain cell polarity. Furthermore, the phosphorylation of Nuf by aPKC allows aPKC to control the sub-cellular localization of Nuf and its own membrane accumulation. Here we review these data and show the different contribution of the 2 Drosophila Rab11 adaptor proteins, Nuf and Rip11, to the maintenance of Drosophila embryonic ectoderm polarity.

Entities: Disease Gene Species

Keywords: Drosophila embryo; Rip11; aPKC; centrosomes; nuclear fallout; trafficking

Mesh：

Substances：

Year: 2016 PMID： 27687567 PMCID： PMC5997155 DOI： 10.1080/21541248.2016.1235386

Source DB: PubMed Journal: Small GTPases ISSN： 2154-1248

32 in total

1. Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs.

Authors: Shirin Meher Pocha; Thomas Wassmer; Christian Niehage; Bernard Hoflack; Elisabeth Knust
Journal: Curr Biol Date: 2011-06-23 Impact factor: 10.834

2. The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization.

Authors: Geert de Vreede; Joshua D Schoenfeld; Sarah L Windler; Holly Morrison; Han Lu; David Bilder
Journal: Development Date: 2014-07 Impact factor: 6.868

3. Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability.

Authors: Marios Georgiou; Eliana Marinari; Jemima Burden; Buzz Baum
Journal: Curr Biol Date: 2008-10-30 Impact factor: 10.834

4. Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis.

Authors: Andrea Leibfried; Robert Fricke; Matthew J Morgan; Sven Bogdan; Yohanns Bellaiche
Journal: Curr Biol Date: 2008-10-30 Impact factor: 10.834

5. The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila.

Authors: Tony J C Harris; Mark Peifer
Journal: J Cell Biol Date: 2005-08-29 Impact factor: 10.539

6. Independent cadherin-catenin and Bazooka clusters interact to assemble adherens junctions.

Authors: Melanie A McGill; R F Andrew McKinley; Tony J C Harris
Journal: J Cell Biol Date: 2009-05-25 Impact factor: 10.539

7. Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm.

Authors: Jeremiah F Roeth; Jessica K Sawyer; Daniel A Wilner; Mark Peifer
Journal: PLoS One Date: 2009-10-28 Impact factor: 3.240

8. Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis.

Authors: Kathryn P Harris; Ulrich Tepass
Journal: J Cell Biol Date: 2008-12-08 Impact factor: 10.539

9. Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system.

Authors: Nicholas W Baetz; James R Goldenring
Journal: Mol Biol Cell Date: 2013-01-02 Impact factor: 4.138