David J Klein1, Adalsteinn D Brown2, Allan S Detsky3. 1. Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada2Institute of Health Policy Management and Evaluation and Department of Medicine, University of Toronto, Toronto, Ontario, Canada. 2. Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada3Institute of Health Policy Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. 3. Institute of Health Policy Management and Evaluation and Department of Medicine, University of Toronto, Toronto, Ontario, Canada4Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada.