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Literature DB >> 27684506

Regional tumour glutamine supply affects chromatin and cell identity.

Abstract

Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of α-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2016 PMID： 27684506 DOI： 10.1038/ncb3414

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

1. Nutrition needs of mammalian cells in tissue culture.

Authors: H EAGLE
Journal: Science Date: 1955-09-16 Impact factor: 47.728

Review 2. Molecular mechanisms and potential functions of histone demethylases.

Authors: Susanne Marije Kooistra; Kristian Helin
Journal: Nat Rev Mol Cell Biol Date: 2012-04-04 Impact factor: 94.444

3. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein.

Authors: Jurre J Kamphorst; Michel Nofal; Cosimo Commisso; Sean R Hackett; Wenyun Lu; Elda Grabocka; Matthew G Vander Heiden; George Miller; Jeffrey A Drebin; Dafna Bar-Sagi; Craig B Thompson; Joshua D Rabinowitz
Journal: Cancer Res Date: 2015-02-01 Impact factor: 12.701

4. High-grade and low-grade gliomas: differentiation by using perfusion MR imaging.

Authors: B Hakyemez; C Erdogan; I Ercan; N Ergin; S Uysal; S Atahan
Journal: Clin Radiol Date: 2005-04 Impact factor: 2.350

5. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.

Authors: Shawn M Davidson; Thales Papagiannakopoulos; Benjamin A Olenchock; Julia E Heyman; Mark A Keibler; Alba Luengo; Matthew R Bauer; Abhishek K Jha; James P O'Brien; Kerry A Pierce; Dan Y Gui; Lucas B Sullivan; Thomas M Wasylenko; Lakshmipriya Subbaraj; Christopher R Chin; Gregory Stephanopolous; Bryan T Mott; Tyler Jacks; Clary B Clish; Matthew G Vander Heiden
Journal: Cell Metab Date: 2016-02-04 Impact factor: 27.287

6. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

Authors: Mariia O Yuneva; Teresa W M Fan; Thaddeus D Allen; Richard M Higashi; Dana V Ferraris; Takashi Tsukamoto; José M Matés; Francisco J Alonso; Chunmei Wang; Youngho Seo; Xin Chen; J Michael Bishop
Journal: Cell Metab Date: 2012-02-08 Impact factor: 27.287

Review 7. Histone lysine demethylases as targets for anticancer therapy.

Authors: Jonas W Højfeldt; Karl Agger; Kristian Helin
Journal: Nat Rev Drug Discov Date: 2013-11-15 Impact factor: 84.694

8. Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.

Authors: Min Pan; Michael A Reid; Xazmin H Lowman; Rajan P Kulkarni; Thai Q Tran; Xiaojing Liu; Ying Yang; Jenny E Hernandez-Davies; Kimberly K Rosales; Haiqing Li; Willy Hugo; Chunying Song; Xiangdong Xu; Dustin E Schones; David K Ann; Viviana Gradinaru; Roger S Lo; Jason W Locasale; Mei Kong
Journal: Nat Cell Biol Date: 2016-09-12 Impact factor: 28.824