| Literature DB >> 27683822 |
Katherine W Kooij1,2, Ferdinand W N M Wit1,3,4,2,5, Thijs Booiman1,6,2, Marc van der Valk3,4, Maarten F Schim van der Loeff3,4,7, Neeltje A Kootstra6, Peter Reiss1,3,4,2,5.
Abstract
Smoking may affect cardiovascular disease risk more strongly in human immunodeficiency virus (HIV)-infected individuals than HIV-uninfected individuals. We hypothesized that an interaction at the level of the immune system may contribute to this increased risk. We assessed soluble markers of inflammation (high-sensitivity C-reactive protein [hsCRP]), immune activation (soluble [s]CD14 and sCD163), and coagulation (D-dimer) in HIV-infected and uninfected never, former, and current smokers. Smoking was independently associated with higher hsCRP levels and lower sCD163 levels and was borderline significantly associated with higher sCD14 and D-dimer levels. We found no evidence of a differential effect of smoking in HIV-infected individuals as compared to uninfected individuals.Entities:
Keywords: HIV infection; coagulation; inflammation; monocyte activation; smoking
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Year: 2016 PMID： 27683822 DOI： 10.1093/infdis/jiw459
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226