Literature DB >> 27683818

Adeno-Associated Virus Serotype 9-Expressed ZMapp in Mice Confers Protection Against Systemic and Airway-Acquired Ebola Virus Infection.

Maria P Limberis1,2, Anna Tretiakova1,3, Kalyani Nambiar1,3, Gary Wong4,5, Trina Racine4,5, Marco Crosariol1,3, Qiu Xiangguo4,5, Gary Kobinger4,5, James M Wilson1,3.   

Abstract

Adeno-associated viral vectors can be used as a platform for delivering biological countermeasures against pandemic and biological threats. We show that vector delivery of two antibody components of the ZMapp product is effective in mice against systemic and airway challenge with a mouse-adapted strain of Ebola virus. This platform provides a generic manufacturing solution and overcomes some of the delivery challenges associated with repeated administration of the protective protein.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Entities:  

Keywords:  airway; animals; infectious disease; prophylaxis; protection; vaccine; vector; virus

Mesh：

Substances：

Year:  2016        PMID： 27683818     DOI： 10.1093/infdis/jiw460

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  10 in total

1.  Intramuscular Adeno-Associated Virus-Mediated Expression of Monoclonal Antibodies Provides 100% Protection Against Ebola Virus Infection in Mice.

Authors:  Laura P van Lieshout; Geoff Soule; Debra Sorensen; Kathy L Frost; Shihua He; Kevin Tierney; David Safronetz; Stephanie A Booth; Gary P Kobinger; Xiangguo Qiu; Sarah K Wootton
Journal:  J Infect Dis       Date:  2018-03-05       Impact factor: 5.226

Review 2.  State of play and clinical prospects of antibody gene transfer.

Authors:  Kevin Hollevoet; Paul J Declerck
Journal:  J Transl Med       Date:  2017-06-07       Impact factor: 5.531

3.  In Vivo Production of Monoclonal Antibodies by Gene Transfer via Electroporation Protects against Lethal Influenza and Ebola Infections.

Authors:  Chasity D Andrews; Yang Luo; Ming Sun; Jian Yu; Arthur J Goff; Pamela J Glass; Neal N Padte; Yaoxing Huang; David D Ho
Journal:  Mol Ther Methods Clin Dev       Date:  2017-09-20       Impact factor: 6.698

4.  In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model.

Authors:  Ami Patel; Daniel H Park; Carl W Davis; Trevor R F Smith; Anders Leung; Kevin Tierney; Aubrey Bryan; Edgar Davidson; Xiaoying Yu; Trina Racine; Charles Reed; Marguerite E Gorman; Megan C Wise; Sarah T C Elliott; Rianne Esquivel; Jian Yan; Jing Chen; Kar Muthumani; Benjamin J Doranz; Erica Ollmann Saphire; James E Crowe; Kate E Broderick; Gary P Kobinger; Shihua He; Xiangguo Qiu; Darwyn Kobasa; Laurent Humeau; Niranjan Y Sardesai; Rafi Ahmed; David B Weiner
Journal:  Cell Rep       Date:  2018-11-13       Impact factor: 9.423

Review 5.  AAV Vectored Immunoprophylaxis for Filovirus Infections.

Authors:  Amira D Rghei; Laura P van Lieshout; Lisa A Santry; Matthew M Guilleman; Sylvia P Thomas; Leonardo Susta; Khalil Karimi; Byram W Bridle; Sarah K Wootton
Journal:  Trop Med Infect Dis       Date:  2020-11-09

Review 6.  Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?

Authors:  Wei Zhan; Manish Muhuri; Phillip W L Tai; Guangping Gao
Journal:  Front Immunol       Date:  2021-05-11       Impact factor: 7.561

Review 7.  In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies.

Authors:  Ami Patel; Mamadou A Bah; David B Weiner
Journal:  BioDrugs       Date:  2020-06       Impact factor: 5.807

Review 8.  The Current and Future State of Vaccines, Antivirals and Gene Therapies Against Emerging Coronaviruses.

Authors:  Longping V Tse; Rita M Meganck; Rachel L Graham; Ralph S Baric
Journal:  Front Microbiol       Date:  2020-04-24       Impact factor: 5.640

Review 9.  Therapeutic Strategies against Ebola Virus Infection.

Authors:  Ching-Hsuan Liu; Yee-Tung Hu; Shu Hui Wong; Liang-Tzung Lin
Journal:  Viruses       Date:  2022-03-11       Impact factor: 5.048

Review 10.  Ebola virus disease: an update on post-exposure prophylaxis.

Authors:  William A Fischer; Pauline Vetter; Daniel G Bausch; Timothy Burgess; Richard T Davey; Robert Fowler; Frederick G Hayden; Peter B Jahrling; Andre C Kalil; Douglas L Mayers; Aneesh K Mehta; Timothy M Uyeki; Michael Jacobs
Journal:  Lancet Infect Dis       Date:  2017-11-15       Impact factor: 25.071
  10 in total

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