Literature DB >> 27683701

Neurotropic cutaneous malignant melanoma with contiguous spread to spinal cord, an extremely rare presentation.

Sheikh Asad1, Idrees Sher1, Jens Peters-Willke1, Peter Jessup1.   

Abstract

Neurotropic melanoma (NM) is a rare variant of cutaneous melanomas. Compared with conventional melanoma, NM is more locally aggressive with an increased tendency for local recurrence but less likely for nodal or distant metastases. The often amelanotic, benign appearance may lead to treatment issues such as late presentation, diagnostic delay, misdiagnosis, insufficient surgical margins, and recurrence with resulting poor outcome. To our knowledge, this is the first case report of NM with contiguous spread to the spinal cord. We present a case report of a 73-year-old male with gradual decline in mobility over the period of few months. He deteriorated very rapidly whilst inpatient with progressive myelopathy, loss of sphincter function and dysphonia with dysphagia due to involvement of lower cranial nerves. The neurotropic nature of the disease and prevalence in the head and neck region results in perineural and neural invasion with resulting neuropathies. Patient underwent posterior cervical decompression and resection of the higher cervical intramedullary spinal cord NM lesion. He recovered well with improvement of his limb weakness as well as bulbar function. Wide local excision (WLE) with adjuvant radiotherapy where indicated remains the current practice for treatment, with chemotherapy predominately being reserved as a salvage treatment for patients with disseminated disease.

Entities:  

Keywords:  Neurotropic; intramedullary spinal cord; melanoma; metastasis

Year:  2016        PMID: 27683701      PMCID: PMC5039844          DOI: 10.21037/jss.2016.03.04

Source DB:  PubMed          Journal:  J Spine Surg        ISSN: 2414-4630


  10 in total

1.  Uncommon manifestations of common malignancies: case 3. Malignant melanoma arising from a spinal nerve root.

Authors:  Aung Naing; Jane L Messina; Frank R Vrionis; Adil I Daud
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Review 2.  Desmoplastic malignant melanoma: a systematic review.

Authors:  M B Lens; J A Newton-Bishop; A P Boon
Journal:  Br J Dermatol       Date:  2005-04       Impact factor: 9.302

3.  The clinical behavior of desmoplastic melanoma.

Authors:  D E Jaroszewski; B A Pockaj; D J DiCaudo; U Bite
Journal:  Am J Surg       Date:  2001-12       Impact factor: 2.565

4.  Neurotropic melanoma. A variant of desmoplastic melanoma.

Authors:  R J Reed; D D Leonard
Journal:  Am J Surg Pathol       Date:  1979-08       Impact factor: 6.394

5.  Desmoplastic neurotropic melanoma: a clinicopathologic analysis of 128 cases.

Authors:  James Y Chen; George Hruby; Richard A Scolyer; Rajmohan Murali; Angela Hong; Patrick Fitzgerald; Trang T Pham; Michael J Quinn; John F Thompson
Journal:  Cancer       Date:  2008-11-15       Impact factor: 6.860

6.  Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma.

Authors:  Katherine E Posther; M Angelica Selim; Paul J Mosca; Wilma E Stanley; Jeffrey L Johnson; Douglas S Tyler; Hilliard F Seigler
Journal:  Ann Surg Oncol       Date:  2006-03-17       Impact factor: 5.344

7.  Perineural spread of malignant melanoma of the head and neck: clinical and imaging features.

Authors:  Patrick C Chang; Nancy J Fischbein; Timothy H McCalmont; Mohammed Kashani-Sabet; Elizabeth M Zettersten; Amon Y Liu; Jane L Weissman
Journal:  AJNR Am J Neuroradiol       Date:  2004-01       Impact factor: 3.825

8.  Desmoplastic and desmoplastic neurotropic melanoma: experience with 280 patients.

Authors:  M J Quinn; K A Crotty; J F Thompson; A S Coates; C J O'Brien; W H McCarthy
Journal:  Cancer       Date:  1998-09-15       Impact factor: 6.860

Review 9.  Malignant melanoma with neural differentiation: an exceptional case report and brief review of the pertinent literature.

Authors:  Albert Su; Sarah M Dry; Scott W Binder; Jonathan Said; Peter Shintaku; G Peter Sarantopoulos
Journal:  Am J Dermatopathol       Date:  2014-01       Impact factor: 1.533

10.  Neurotropic melanoma: the management of localised disease.

Authors:  Jeremy Croker; Bryan Burmeister; Matthew Foote
Journal:  J Skin Cancer       Date:  2012-10-22
  10 in total
  1 in total

1.  Intramedullary Spinal Cord Metastases from Differentiated Thyroid Cancer, a Case Report.

Authors:  Fabio Volpe; Leandra Piscopo; Mariarosaria Manganelli; Maria Falzarano; Federica Volpicelli; Carmela Nappi; Massimo Imbriaco; Alberto Cuocolo; Michele Klain
Journal:  Life (Basel)       Date:  2022-06-09
  1 in total

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