Rossiana I Bojinova1,2, Cengiz Türksever1, Andreas Schötzau1, Christophe Valmaggia3, Daniel F Schorderet4,5,6, Margarita G Todorova1. 1. Department of Ophthalmology, University of Basel, Basel, Switzerland. 2. McGill University, Montreal, Canada. 3. Department of Ophthalmology, Cantonal Hospital, St. Gallen, Switzerland. 4. IRO - Institute for Research in Ophthalmology, Sion, Switzerland. 5. Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland. 6. School of Life Sciences, Federal Institute of Technology, Lausanne, Switzerland.
Abstract
PURPOSE: To evaluate the relationship between the peripapillary metabolic alterations [retinal vessel Oximetry (RO)] and the structural findings [retinal vessel diameter and retinal nerve fibre layer thickness (RNFL)] in patients with inherited retinal dystrophies (IRD). METHODS: Patients with IRD [24 patients with rod-cone dystrophy (RCD), 15 patients with cone-rod dystrophy, 13 patients with inherited maculopathy] and 18 age-matched controls, who underwent RO imaging and spectral domain optical coherence tomography, were included. The average and quadrant oxygen saturation in all four major peripapillary retinal arterioles (A-SO2 ) and venules (V-SO2 ) were measured, and their difference (A-V SO2 ) was calculated. The corresponding retinal vessel diameter of these arterioles (D-A) and venules (D-V) was measured. The data were compared to the peripapillary RNFL thickness within the IRD subgroups and to the data obtained in the controls. RESULTS: In general, patients with IRD had higher average V-SO2 values when compared to controls (p ≤ 0.029). Rod-cone dystrophy (RCD) patients differed from controls, but also from patients with other IRDs, when the average and quadrant oxygen saturation values (A-SO2 and V-SO2 ) were evaluated (p ≤ 0.026). Within the RCD group, the correlations of RNFL thickness to V-SO2 , A-V SO2 , D-A and D-V were significant (p ≤ 0.030), thus indicating a different relationship between the RNFL thickness and the examined parameters, when compared to the other groups. CONCLUSION: It becomes evident from our combined metabolic-structural approach that a prediction model, to identify which individual is at risk of developing a photoreceptor degeneration of RCD type, can be proposed. It will take into account the peripapillary retinal oxygen saturation, the retinal vessel diameter and the RNFL thickness values.
PURPOSE: To evaluate the relationship between the peripapillary metabolic alterations [retinal vessel Oximetry (RO)] and the structural findings [retinal vessel diameter and retinal nerve fibre layer thickness (RNFL)] in patients with inherited retinal dystrophies (IRD). METHODS:Patients with IRD [24 patients with rod-cone dystrophy (RCD), 15 patients with cone-rod dystrophy, 13 patients with inherited maculopathy] and 18 age-matched controls, who underwent RO imaging and spectral domain optical coherence tomography, were included. The average and quadrant oxygen saturation in all four major peripapillary retinal arterioles (A-SO2 ) and venules (V-SO2 ) were measured, and their difference (A-V SO2 ) was calculated. The corresponding retinal vessel diameter of these arterioles (D-A) and venules (D-V) was measured. The data were compared to the peripapillary RNFL thickness within the IRD subgroups and to the data obtained in the controls. RESULTS: In general, patients with IRD had higher average V-SO2 values when compared to controls (p ≤ 0.029). Rod-cone dystrophy (RCD) patients differed from controls, but also from patients with other IRDs, when the average and quadrant oxygen saturation values (A-SO2 and V-SO2 ) were evaluated (p ≤ 0.026). Within the RCD group, the correlations of RNFL thickness to V-SO2 , A-V SO2 , D-A and D-V were significant (p ≤ 0.030), thus indicating a different relationship between the RNFL thickness and the examined parameters, when compared to the other groups. CONCLUSION: It becomes evident from our combined metabolic-structural approach that a prediction model, to identify which individual is at risk of developing a photoreceptor degeneration of RCD type, can be proposed. It will take into account the peripapillary retinal oxygen saturation, the retinal vessel diameter and the RNFL thickness values.
Authors: Margarita G Todorova; Hendrik P N Scholl; Maria Della Volpe Waizel Journal: Graefes Arch Clin Exp Ophthalmol Date: 2020-09-10 Impact factor: 3.117
Authors: Rossiana I Bojinova; Daniel F Schorderet; Christophe Valmaggia; Cengiz Türksever; Andreas Schoetzau; Margarita G Todorova Journal: Eye (Lond) Date: 2018-03-06 Impact factor: 3.775
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Authors: Maria Della Volpe-Waizel; Hanna Camenzind Zuche; Ursula Müller; Annekatrin Rickmann; Hendrik P N Scholl; Margarita G Todorova Journal: Graefes Arch Clin Exp Ophthalmol Date: 2019-11-12 Impact factor: 3.117
Authors: Annekatrin Rickmann; Maria Della Volpe Waizel; Olga Zabek; Hanna Camenzind Zuche; Ursula Müller; Hendrik P N Scholl Journal: Graefes Arch Clin Exp Ophthalmol Date: 2020-10-10 Impact factor: 3.117
Authors: Theresa H Birtel; Johannes Birtel; Kristina Hess; Amelie C Clemens; Moritz Lindner; Philipp Herrmann; Frank G Holz; Martin Gliem Journal: Graefes Arch Clin Exp Ophthalmol Date: 2021-07-21 Impact factor: 3.117