R Strohal1, B Assenheimer2,3, M Augustin4, G Hämmerle5, S Läuchli6, B Pundt7, G Stern8, M Storck9, C Ulrich10. 1. Abteilung für Dermatologie und Venerologie, LKH Feldkirch, Akademisches Lehrspital, Carinagasse 45-47, 6800, Feldkirch, Österreich. robert.strohal@lkhf.at. 2. Arbeitsgruppe Dekubitus/Wundpflege, Universitätsklinikum Tübingen, Geissweg 3, 72076, Tübingen, Deutschland. 3. Initiative Chronische Wunden e. V., Pölle 27/28, 06484, Quedlinburg, Deutschland. 4. Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland. 5. Wundambulanz, LKH Bregenz, Carl-Pedenz-Str. 2, 6900, Bregenz, Österreich. 6. Dermatologische Klinik, Universitätsspital Zürich, Gloriastr. 31, 8091, Zürich, Schweiz. 7. Gemeinschaftspraxis für Allgemeinmedizin, Bahnhofstr. 18, 26180, Rastede, Deutschland. 8. Ambulantes-Therapie-Zentrum ATZ Stern, Barloer Weg 127b, 46397, Bocholt, Deutschland. 9. Klinik für Gefäß- und Thoraxchirurgie, Städt. Klinikum Karlsruhe, Moltkestr. 90, 76133, Karlsruhe, Deutschland. 10. Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
Abstract
BACKGROUND: The challenges of modern wound management, such as the treatment of chronic wounds and their phase-specific handling, are demanding and require optimally adapted therapeutic measures. The principles of moist wound care as well as an adequate debridement have priority here. To support these necessary measures, different options are available, e.g., a new product group operating across several wound phases. OBJECTIVE: A new treatment principle in modern wound management based on an expert consensus is presented. METHODS: On the basis of clinical experience reports and published evidence, the current and new principles of wound treatment were discussed in a panel of experts and formulated as a consensus statement. RESULTS: Enzyme alginogels represent a combination of agents that allow phase-specific wound care. They exhibit autolytic, absorbent, and antimicrobial properties and simultaneously cover three components of wound management based on the TIME framework. Thus, according to the experts, they differ from other wound healing products and can be classified in a distinct product group. Clinical studies, as well as clinical experiences, provide evidence for the efficacy of enzyme alginogels. DISCUSSION: According to the experts, the potential of enzyme alginogels used considering the principles of moist wound care, comprises the three-fold effect (continuous and significantly simplified debridement, maintaining a moist wound environment and antimicrobial effect without cytotoxicity), the ease of use, and the flexible application. In addition, the flexibility of the product class regarding frequency of application, duration of treatment and combinability with secondary dressings, are of economic benefit in the health care sector.
BACKGROUND: The challenges of modern wound management, such as the treatment of chronic wounds and their phase-specific handling, are demanding and require optimally adapted therapeutic measures. The principles of moist wound care as well as an adequate debridement have priority here. To support these necessary measures, different options are available, e.g., a new product group operating across several wound phases. OBJECTIVE: A new treatment principle in modern wound management based on an expert consensus is presented. METHODS: On the basis of clinical experience reports and published evidence, the current and new principles of wound treatment were discussed in a panel of experts and formulated as a consensus statement. RESULTS: Enzyme alginogels represent a combination of agents that allow phase-specific wound care. They exhibit autolytic, absorbent, and antimicrobial properties and simultaneously cover three components of wound management based on the TIME framework. Thus, according to the experts, they differ from other wound healing products and can be classified in a distinct product group. Clinical studies, as well as clinical experiences, provide evidence for the efficacy of enzyme alginogels. DISCUSSION: According to the experts, the potential of enzyme alginogels used considering the principles of moist wound care, comprises the three-fold effect (continuous and significantly simplified debridement, maintaining a moist wound environment and antimicrobial effect without cytotoxicity), the ease of use, and the flexible application. In addition, the flexibility of the product class regarding frequency of application, duration of treatment and combinability with secondary dressings, are of economic benefit in the health care sector.
Authors: Eugenia Kyriopoulos; D Van den Plas; O Papadopoulos; S Papadopoulos; P Zapandioti; D Tsoutsos Journal: Wounds Date: 2010-06 Impact factor: 1.546
Authors: Robert Strohal; J Dissemond; J Jordan O'Brien; A Piaggesi; R Rimdeika; T Young; J Apelqvist Journal: J Wound Care Date: 2013-01 Impact factor: 2.072