Literature DB >> 27677730

No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival.

Lara E Sucheston-Campbell1, Rikki Cannioto2, Alyssa I Clay3, John Lewis Etter2, Kevin H Eng4, Song Liu4, Sebastiano Battaglia5, Qiang Hu4, J Brian Szender6, Albina Minlikeeva2, Janine M Joseph2, Paul Mayor6, Scott I Abrams7, Brahm H Segal7,8, Paul K Wallace9, Kah Teong Soh9, Emese Zsiros6, Hoda Anton-Culver10, Elisa V Bandera11, Matthias W Beckmann12, Andrew Berchuck13, Line Bjorge14,15, Amanda Bruegl16, Ian G Campbell17,18, Shawn Patrice Campbell16, Georgia Chenevix-Trench, Daniel W Cramer19,20, Agnieszka Dansonka-Mieszkowska21, Fanny Dao22, Brenda Diergaarde23, Thilo Doerk24, Jennifer A Doherty25, Andreas du Bois26,27, Diana Eccles28,29, Svend Aage Engelholm30, Peter A Fasching12, Simon A Gayther31,32, Aleksandra Gentry-Maharaj33, Rosalind M Glasspool34, Marc T Goodman35,36, Jacek Gronwald37, Philipp Harter26, Alexander Hein12, Florian Heitz26,27, Peter Hillemmanns24, Claus Høgdall38, Estrid V S Høgdall39,40, Tomasz Huzarski37, Allan Jensen39, Sharon E Johnatty41, Audrey Jung42,43, Beth Y Karlan44, Reudiger Klapdor24, Tomasz Kluz45, Bożena Konopka21, Susanne Krüger Kjær38,39, Jolanta Kupryjanczyk21, Diether Lambrechts46, Jenny Lester44, Jan Lubiński37, Douglas A Levine22, Lene Lundvall47, Valerie McGuire48, Iain A McNeish49, Usha Menon33, Francesmary Modugno23,50,51, Roberta B Ness52, Sandra Orsulic44, James Paul34, Celeste Leigh Pearce53,54, Tanja Pejovic16,55, Paul Pharoah56,57, Susan J Ramus58,59, Joseph Rothstein48, Mary Anne Rossing60,61, Matthias Rübner12, Joellen M Schildkraut62, Barbara Schmalfeldt63, Ira Schwaab64, Nadeem Siddiqui65, Weiva Sieh66,67, Piotr Sobiczewski68, Honglin Song56, Kathryn L Terry19,20, Els Van Nieuwenhuysen69, Adriaan Vanderstichele69, Ignace Vergote69, Christine S Walsh44, Penelope M Webb70, Nicolas Wentzensen71, Alice S Whittemore48, Anna H Wu54, Argyrios Ziogas72, Kunle Odunsi6, Jenny Chang-Claude42,43, Ellen L Goode73, Kirsten B Moysich74.   

Abstract

Background: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immunosuppressive/protumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be a prominent mechanism contributing to immunologic tolerance of malignant cells in epithelial ovarian cancer (EOC). To this end, we hypothesized genetic variation in MDSC pathway genes would be associated with survival after EOC diagnoses.
Methods: We measured the hazard of death due to EOC within 10 years of diagnosis, overall and by invasive subtype, attributable to SNPs in 24 genes relevant in the MDSC pathway in 10,751 women diagnosed with invasive EOC. Versatile Gene-based Association Study and the admixture likelihood method were used to test gene and pathway associations with survival.
Results: We did not identify individual SNPs that were significantly associated with survival after correction for multiple testing (P < 3.5 × 10-5), nor did we identify significant associations between the MDSC pathway overall, or the 24 individual genes and EOC survival.Conclusions: In this well-powered analysis, we observed no evidence that inherited variations in MDSC-associated SNPs, individual genes, or the collective genetic pathway contributed to EOC survival outcomes.Impact: Common inherited variation in genes relevant to MDSCs was not associated with survival in women diagnosed with invasive EOC. Cancer Epidemiol Biomarkers Prev; 26(3); 420-4. ©2016 AACR. ©2016 American Association for Cancer Research.

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Mesh:

Year:  2016        PMID: 27677730      PMCID: PMC5500198          DOI: 10.1158/1055-9965.EPI-16-0631

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.254


  7 in total

1.  A versatile gene-based test for genome-wide association studies.

Authors:  Jimmy Z Liu; Allan F McRae; Dale R Nyholt; Sarah E Medland; Naomi R Wray; Kevin M Brown; Nicholas K Hayward; Grant W Montgomery; Peter M Visscher; Nicholas G Martin; Stuart Macgregor
Journal:  Am J Hum Genet       Date:  2010-07-09       Impact factor: 11.025

2.  The admixture maximum likelihood test: a novel experiment-wise test of association between disease and multiple SNPs.

Authors:  Jonathan Tyrer; Paul D P Pharoah; Douglas F Easton
Journal:  Genet Epidemiol       Date:  2006-11       Impact factor: 2.135

3.  Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy.

Authors:  C Marcela Diaz-Montero; Mohamed Labib Salem; Michael I Nishimura; Elizabeth Garrett-Mayer; David J Cole; Alberto J Montero
Journal:  Cancer Immunol Immunother       Date:  2008-04-30       Impact factor: 6.968

4.  IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients.

Authors:  Susanna Mandruzzato; Samantha Solito; Erika Falisi; Samuela Francescato; Vanna Chiarion-Sileni; Simone Mocellin; Antonio Zanon; Carlo R Rossi; Donato Nitti; Vincenzo Bronte; Paola Zanovello
Journal:  J Immunol       Date:  2009-05-15       Impact factor: 5.422

5.  Germline copy number variation and ovarian cancer survival.

Authors:  Brooke L Fridley; Prabhakar Chalise; Ya-Yu Tsai; Zhifu Sun; Robert A Vierkant; Melissa C Larson; Julie M Cunningham; Edwin S Iversen; David Fenstermacher; Jill Barnholtz-Sloan; Yan Asmann; Harvey A Risch; Joellen M Schildkraut; Catherine M Phelan; Rebecca Sutphen; Thomas A Sellers; Ellen L Goode
Journal:  Front Genet       Date:  2012-08-08       Impact factor: 4.599

6.  Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.

Authors:  Shalaka S Hampras; Lara E Sucheston-Campbell; Rikki Cannioto; Jenny Chang-Claude; Francesmary Modugno; Thilo Dörk; Peter Hillemanns; Leah Preus; Keith L Knutson; Paul K Wallace; Chi-Chen Hong; Grace Friel; Warren Davis; Mary Nesline; Celeste L Pearce; Linda E Kelemen; Marc T Goodman; Elisa V Bandera; Kathryn L Terry; Nils Schoof; Kevin H Eng; Alyssa Clay; Prashant K Singh; Janine M Joseph; Katja K H Aben; Hoda Anton-Culver; Natalia Antonenkova; Helen Baker; Yukie Bean; Matthias W Beckmann; Maria Bisogna; Line Bjorge; Natalia Bogdanova; Louise A Brinton; Angela Brooks-Wilson; Fiona Bruinsma; Ralf Butzow; Ian G Campbell; Karen Carty; Linda S Cook; Daniel W Cramer; Cezary Cybulski; Agnieszka Dansonka-Mieszkowska; Joe Dennis; Evelyn Despierre; Ed Dicks; Jennifer A Doherty; Andreas du Bois; Matthias Dürst; Doug Easton; Diana Eccles; Robert P Edwards; Arif B Ekici; Peter A Fasching; Brooke L Fridley; Yu-Tang Gao; Aleksandra Gentry-Maharaj; Graham G Giles; Rosalind Glasspool; Jacek Gronwald; Patricia Harrington; Philipp Harter; Hanis Nazihah Hasmad; Alexander Hein; Florian Heitz; Michelle A T Hildebrandt; Claus Hogdall; Estrid Hogdall; Satoyo Hosono; Edwin S Iversen; Anna Jakubowska; Allan Jensen; Bu-Tian Ji; Beth Y Karlan; Melissa Kellar; Joseph L Kelley; Lambertus A Kiemeney; Rüdiger Klapdor; Nonna Kolomeyevskaya; Camilla Krakstad; Susanne K Kjaer; Bridget Kruszka; Jolanta Kupryjanczyk; Diether Lambrechts; Sandrina Lambrechts; Nhu D Le; Alice W Lee; Shashikant Lele; Arto Leminen; Jenny Lester; Douglas A Levine; Dong Liang; Jolanta Lissowska; Song Liu; Karen Lu; Jan Lubinski; Lene Lundvall; Leon F A G Massuger; Keitaro Matsuo; Valeria McGuire; John R McLaughlin; Ian McNeish; Usha Menon; Joanna Moes-Sosnowska; Steven A Narod; Lotte Nedergaard; Heli Nevanlinna; Stefan Nickels; Sara H Olson; Irene Orlow; Rachel Palmieri Weber; James Paul; Tanja Pejovic; Liisa M Pelttari; Barbara Perkins; Jenny Permuth-Wey; Malcolm C Pike; Joanna Plisiecka-Halasa; Elizabeth M Poole; Harvey A Risch; Mary Anne Rossing; Joseph H Rothstein; Anja Rudolph; Ingo B Runnebaum; Iwona K Rzepecka; Helga B Salvesen; Eva Schernhammer; Kristina Schmitt; Ira Schwaab; Xiao-Ou Shu; Yurii B Shvetsov; Nadeem Siddiqui; Weiva Sieh; Honglin Song; Melissa C Southey; Ingvild L Tangen; Soo-Hwang Teo; Pamela J Thompson; Agnieszka Timorek; Ya-Yu Tsai; Shelley S Tworoger; Jonathan Tyrer; Anna M van Altena; Ignace Vergote; Robert A Vierkant; Christine Walsh; Shan Wang-Gohrke; Nicolas Wentzensen; Alice S Whittemore; Kristine G Wicklund; Lynne R Wilkens; Anna H Wu; Xifeng Wu; Yin-Ling Woo; Hannah Yang; Wei Zheng; Argyrios Ziogas; Simon A Gayther; Susan J Ramus; Thomas A Sellers; Joellen M Schildkraut; Catherine M Phelan; Andrew Berchuck; Georgia Chenevix-Trench; Julie M Cunningham; Paul P Pharoah; Roberta B Ness; Kunle Odunsi; Ellen L Goode; Kirsten B Moysich
Journal:  Oncotarget       Date:  2016-10-25

7.  Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.

Authors:  Juliet D French; Sharon E Johnatty; Yi Lu; Jonathan Beesley; Bo Gao; Murugan Kalimutho; Michelle J Henderson; Amanda J Russell; Siddhartha Kar; Xiaoqing Chen; Kristine M Hillman; Susanne Kaufmann; Haran Sivakumaran; Martin O'Reilly; Chen Wang; Darren J Korbie; Diether Lambrechts; Evelyn Despierre; Els Van Nieuwenhuysen; Sandrina Lambrechts; Ignace Vergote; Beth Karlan; Jenny Lester; Sandra Orsulic; Christine Walsh; Peter A Fasching; Matthias W Beckmann; Arif B Ekici; Alexander Hein; Keitaro Matsuo; Satoyo Hosono; Jacobus Pisterer; Peter Hillemanns; Toru Nakanishi; Yasushi Yatabe; Marc T Goodman; Galina Lurie; Rayna K Matsuno; Pamela J Thompson; Tanja Pejovic; Yukie Bean; Florian Heitz; Philipp Harter; Andreas du Bois; Ira Schwaab; Estrid Hogdall; Susanne K Kjaer; Allan Jensen; Claus Hogdall; Lene Lundvall; Svend Aage Engelholm; Bob Brown; James M Flanagan; Michelle D Metcalf; Nadeem Siddiqui; Thomas Sellers; Brooke Fridley; Julie Cunningham; Joellen M Schildkraut; Ed Iversen; Rachel Palmieri Weber; Donal Brennan; Andrew Berchuck; Paul Pharoah; Paul Harnett; Murray D Norris; Michelle Haber; Ellen L Goode; Jason S Lee; Kum Kum Khanna; Kerstin B Meyer; Georgia Chenevix-Trench; Anna deFazio; Stacey L Edwards; Stuart MacGregor
Journal:  Oncotarget       Date:  2016-02-09
  7 in total
  2 in total

Review 1.  A Call for Epidemiological Research on Myeloid-Derived Suppressor Cells in Ovarian Cancer: A Review of the Existing Immunological Evidence and Suggestions for Moving Forward.

Authors:  Ashley E Stenzel; Scott I Abrams; Kirsten B Moysich
Journal:  Front Immunol       Date:  2019-07-09       Impact factor: 8.786

2.  Germline polymorphisms in myeloid-associated genes are not associated with survival in glioma patients.

Authors:  Daniel I Jacobs; Yanhong Liu; Konrad Gabrusiewicz; Spiridon Tsavachidis; Georgina N Armstrong; Renke Zhou; Jun Wei; Cristina Ivan; George Calin; Annette M Molinaro; Terri Rice; Paige M Bracci; Helen M Hansen; John K Wiencke; Margaret R Wrensch; Amy B Heimberger; Melissa L Bondy
Journal:  J Neurooncol       Date:  2017-09-30       Impact factor: 4.506

  2 in total

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