| Literature DB >> 2767683 |
R A Lothe1, S D Fosså, A E Stenwig, Y Nakamura, R White, A L Børresen, A Brøgger.
Abstract
Constitutional and tumor genotypes defined by polymorphic DNA markers were examined in 31 testicular cancer patients. Constitutional karyotypes were analyzed and clinical data presented. We analyzed 11 loci representing 8 chromosomes, including regions frequently deleted in other types of cancer. Loss of 3p or 11p sequences was detected in 8 of 28 heterozygotes (28%) and in 5 of 20 heterozygotes (25%). This gives a combined total loss of 40%. The other autosomal loci tested showed no loss or a loss of less than 10% of alleles. We suggest that this loss of heterozygosity for genetic material on chromosome 3p or on 11p is nonrandom and important in the development of a major subset of testicular neoplasms.Entities:
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Year: 1989 PMID： 2767683 DOI： 10.1016/0888-7543(89)90097-9
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736