Literature DB >> 27672409

Improving Treatment of Erythematotelangiectatic Rosacea with Laser and/or Topical Therapy Through Enhanced Discrimination of its Clinical Features.

Giuseppe Micali1, Peter Arne Gerber1, Francesco Lacarrubba2, Gregor Schäfer3.   

Abstract

Rosacea is a chronic inflammatory disease that can present with a variety of cutaneous symptoms. Erythematotelangiectatic rosacea is a subtype characterized by flushing (transient erythema), persistent central facial erythema (background erythema), and telangiectasias. The severity of individual symptoms differs in each patient, which can complicate the selection of an appropriate treatment strategy. Evaluation of these specific symptoms has been greatly improved by the routine use of diagnostic tools such as (video) dermatoscopy. Following a thorough clinical assessment, treatment decisions should be made based on the proportion of these individual symptoms in individual patients. Brimonidine 0.33% gel is recommended in the symptomatic treatment of facial erythema, and there is evidence for the efficacy of laser/light-based therapies in the treatment of erythema and telangiectasias. In patients presenting with both marked background erythema and telangiectasias, initial treatment with brimonidine 0.33% gel to target the erythema followed by laser/light-based therapy for the telangiectasias has been shown to be an effective combination in clinical practice. This article aims to facilitate treatment decision-making in clinical practice through: 1) better differentiation of the main symptoms of erythematotelangiectatic rosacea and 2) practical advice for the selection of appropriate treatments, based on clinical case examples.

Entities:  

Year:  2016        PMID: 27672409      PMCID: PMC5023001     

Source DB:  PubMed          Journal:  J Clin Aesthet Dermatol        ISSN: 1941-2789


  49 in total

1.  Neodymium-yttrium aluminum garnet laser versus pulsed dye laser in erythemato-telangiectatic rosacea: comparison of clinical efficacy and effect on cutaneous substance (P) expression.

Authors:  Samar Abdallah M Salem; Nermeen S A Abdel Fattah; Samah M A Tantawy; Nafissa M A El-Badawy; Yasser A Abd El-Aziz
Journal:  J Cosmet Dermatol       Date:  2013-09       Impact factor: 2.696

2.  Standard management options for rosacea, part 1: overview and broad spectrum of care.

Authors:  Richard Odom; Mark Dahl; Jeffrey Dover; Zoe Draelos; Lynn Drake; Marian Macsai; Frank Powell; Diane Thiboutot; Guy F Webster; Jonathan Wilkin
Journal:  Cutis       Date:  2009-07

Review 3.  Rosacea under the microscope: characteristic histological findings.

Authors:  B Cribier
Journal:  J Eur Acad Dermatol Venereol       Date:  2013-03-04       Impact factor: 6.166

4.  A split-face comparison study of pulsed 532-nm KTP laser and 595-nm pulsed dye laser in the treatment of facial telangiectasias and diffuse telangiectatic facial erythema.

Authors:  Nathan S Uebelhoer; Melissa A Bogle; Brigitte Stewart; Kenneth A Arndt; Jeffrey S Dover
Journal:  Dermatol Surg       Date:  2007-04       Impact factor: 3.398

5.  Clinical, Histologic, and Molecular Analysis of Differences Between Erythematotelangiectatic Rosacea and Telangiectatic Photoaging.

Authors:  Yolanda R Helfrich; Lisa E Maier; Yilei Cui; Gary J Fisher; Heather Chubb; Suzanne Fligiel; Dana Sachs; James Varani; John Voorhees
Journal:  JAMA Dermatol       Date:  2015-08       Impact factor: 10.282

6.  Optimizing the use of topical brimonidine in rosacea management: panel recommendations.

Authors:  Emil A Tanghetti; J Mark Jackson; Kevin Tate Belasco; Amanda Friedrichs; Firas Hougier; Sandra Marchese Johnson; Francisco A Kerdel; Dimitry Palceski; H Chih-Ho Hong; Anna Hinek; Maria Jose Rueda Cadena
Journal:  J Drugs Dermatol       Date:  2015-01       Impact factor: 2.114

7.  Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.

Authors:  Xi-Ping Huang; Vincent Setola; Prem N Yadav; John A Allen; Sarah C Rogan; Bonnie J Hanson; Chetana Revankar; Matt Robers; Chris Doucette; Bryan L Roth
Journal:  Mol Pharmacol       Date:  2009-07-01       Impact factor: 4.436

8.  An observational cross-sectional survey of rosacea: clinical associations and progression between subtypes.

Authors:  J Tan; U Blume-Peytavi; J P Ortonne; K Wilhelm; L Marticou; E Baltas; M Rivier; L Petit; P Martel
Journal:  Br J Dermatol       Date:  2013-09       Impact factor: 9.302

Review 9.  Devices and topical agents for rosacea management.

Authors:  Yasaman Mansouri; Gary Goldenberg
Journal:  Cutis       Date:  2014-07

10.  Mast cells are key mediators of cathelicidin-initiated skin inflammation in rosacea.

Authors:  Yumiko Muto; Zhenping Wang; Matthieu Vanderberghe; Aimee Two; Richard L Gallo; Anna Di Nardo
Journal:  J Invest Dermatol       Date:  2014-05-20       Impact factor: 8.551

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  5 in total

1.  Treatment of erythematotelangiectatic rosacea, facial erythema, and facial telangiectasia with a 577-nm pro-yellow laser: a case series.

Authors:  Yelda Kapicioglu; Gulbahar Sarac; Hulya Cenk
Journal:  Lasers Med Sci       Date:  2018-08-10       Impact factor: 3.161

Review 2.  Treatment for telangiectasias and reticular veins.

Authors:  Luis Cu Nakano; Daniel G Cacione; Jose Cc Baptista-Silva; Ronald Lg Flumignan
Journal:  Cochrane Database Syst Rev       Date:  2021-10-12

3.  Treatment of erythemato-telangiectatic rosacea with brimonidine alone or combined with vascular laser based on preliminary instrumental evaluation of the vascular component.

Authors:  Giuseppe Micali; Federica Dall'Oglio; Anna Elisa Verzì; Ivano Luppino; Karishma Bhatt; Francesco Lacarrubba
Journal:  Lasers Med Sci       Date:  2017-09-09       Impact factor: 3.161

4.  Clinical and instrumental evaluation of a new topical non-corticosteroid antifungal/anti-inflammatory/antiseborrheic combination cream for the treatment of mild-to-moderate facial seborrheic dermatitis.

Authors:  Federica Dall'Oglio; Francesco Lacarrubba; Maria Luca; Simona Boscaglia; Corinne Granger; Giuseppe Micali
Journal:  Clin Cosmet Investig Dermatol       Date:  2019-01-24

5.  A novel azelaic acid formulation for the topical treatment of inflammatory rosacea: A multicentre, prospective clinical trial.

Authors:  Federica Dall'Oglio; Aurora Tedeschi; Francesco Lacarrubba; Gabriella Fabbrocini; Nevena Skroza; Paolo Chiodini; Giuseppe Micali
Journal:  J Cosmet Dermatol       Date:  2021-04       Impact factor: 2.696

  5 in total

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