| Literature DB >> 27671722 |
Grace Patlewicz1,2, Andrew P Worth3, Nicholas Ball4.
Abstract
In this chapter, we provide an overview of how (Quantitative) Structure Activity Relationships, (Q)SARs, are validated and applied for regulatory purposes. We outline how chemical categories are derived to facilitate endpoint specific read-across using tools such as the OECD QSAR Toolbox and discuss some of the current difficulties in addressing the residual uncertainties of read-across. Finally we put forward a perspective of how non-testing approaches may evolve in light of the advances in new and emerging technologies and how these fit within the Adverse Outcome Pathway (AOP) framework.Keywords: (Quantitative) Structure Activity Relationship [(Q)SAR]; Adverse Outcome Pathways (AOPs); Integrated Approaches to Testing and Assessment (IATA); OECD Validation Principles; Read-across
Mesh：
Year: 2016 PMID： 27671722 DOI： 10.1007/978-3-319-33826-2_6
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622