Literature DB >> 27671064

Mycobacterium tuberculosis Arylamine N-Acetyltransferase Acetylates and Thus Inactivates para-Aminosalicylic Acid.

Xude Wang1,2, Shanshan Yang1, Jing Gu1, Jiaoyu Deng3.   

Abstract

Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) is able to acetylate para-aminosalicylic acid (PAS) both in vitro and in vivo as determined by high-performance liquid chromatography (HPLC) and electrospray ionization-mass spectrometry (ESI-MS) techniques. The antituberculosis activity of the acetylated PAS is significantly reduced. As a result, overexpression of TBNAT in M. tuberculosis results in PAS resistance, as determined by MIC tests and drug exposure experiments. Taken together, our results suggest that TBNAT from M. tuberculosis is able to inactivate PAS by acetylating the compound.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27671064      PMCID： PMC5119037          DOI： 10.1128/AAC.01312-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

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Journal:  Lancet       Date:  1946-01-05       Impact factor: 79.321

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Authors:  Elizabeth Fullam; Akane Kawamura; Helen Wilkinson; Areej Abuhammad; Isaac Westwood; Edith Sim
Journal:  Protein J       Date:  2009-08       Impact factor: 2.371

5.  Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis.

Authors:  Alison L Sikora; Brenda A Frankel; John S Blanchard
Journal:  Biochemistry       Date:  2008-09-17       Impact factor: 3.162

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Journal:  J Biol Chem       Date:  1990-03-15       Impact factor: 5.157

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8.  Involvement of Cys69 residue in the catalytic mechanism of N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium. Sequence similarity at the amino acid level suggests a common catalytic mechanism of acetyltransferase for S. typhimurium and higher organisms.

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Journal:  J Biol Chem       Date:  1992-04-25       Impact factor: 5.157

9.  Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research.

Authors:  Masanari Kitagawa; Takeshi Ara; Mohammad Arifuzzaman; Tomoko Ioka-Nakamichi; Eiji Inamoto; Hiromi Toyonaga; Hirotada Mori
Journal:  DNA Res       Date:  2006-01-09       Impact factor: 4.458

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Authors:  Edith Sim; Nathan Lack; Chan-Ju Wang; Hilary Long; Isaac Westwood; Elizabeth Fullam; Akane Kawamura
Journal:  Toxicology       Date:  2008-09-12       Impact factor: 4.221
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  3 in total

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Journal:  World J Microbiol Biotechnol       Date:  2019-10-31       Impact factor: 3.312

2.  Acetylation of Isoniazid Is a Novel Mechanism of Isoniazid Resistance in Mycobacterium tuberculosis.

Authors:  K B Arun; Aravind Madhavan; Billu Abraham; M Balaji; K C Sivakumar; P Nisha; R Ajay Kumar
Journal:  Antimicrob Agents Chemother       Date:  2020-12-16       Impact factor: 5.191

3.  Identification of new arylamine N-acetyltransferases and enhancing 2-acetamidophenol production in Pseudomonas chlororaphis HT66.

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Journal:  Microb Cell Fact       Date:  2020-05-19       Impact factor: 5.328
  3 in total

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