Xiaoli Zhang 1 , Jiyong Wu 1 , Yepeng Luan 2 Show Affiliations »
Abstract
BACKGROUND: Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates. RESULTS: Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers. CONCLUSION: Here, main functions and its known inhibitors were summarized. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Tip60 , the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat . Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates. RESULTS: Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers . CONCLUSION: Here, main functions and its known inhibitors were summarized. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Disease
Gene
Species
Keywords:
Cancer; HATs; HDACs; Tip60; histone acetyltransferase; inhibitor; ε-amino
Mesh： See more »
Substances： See more »
Year: 2017
PMID： 27670582 DOI： 10.2174/1389557516666160923125031
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862