Literature DB >> 27670581

Roles of Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Anticancer Agents.

Supaluk Prachayasittikul1, Ratchanok Pingaew2, Apilak Worachartcheewan1, Nujarin Sinthupoom3, Veda Prachayasittikul3, Somsak Ruchirawat4, Virapong Prachayasittikul3.   

Abstract

BACKGROUND: Cancer has been considered to be a global health concern due to the impact of disease on the quality of life. The continual increase of cancer cases as well as the resistance of cancer cells to the existing drugs have driven the search for novel anticancer drugs with better potency and selectivity, improved pharmacokinetic profiles, and minimum toxicities. Pyridine and pyrimidine are presented in natural products and genetic materials. These pyridine/pyrimidine core structures have been noted for their roles in many biological processes as well as in cancer pathogenesis, which make such compounds become attractive scaffolds for discovery of novel drugs. RESULTS &
CONCLUSION: In the recent years, pyridine- and pyrimidine-based anticancer drugs have been developed based on structural modification of these core structures (i.e., substitution with moieties and rings, conjugation with other compounds, and coordination with metal ions). Detailed discussion is provided in this review to highlight the potential of these small molecules as privileged scaffolds with attractive properties and biological activities for the search of novel anticancer agents. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Anticancer agents; cancer; fused-pyridine/pyrimidine; metal-based pyridine/pyrimidine; pyridine; pyrimidine

Mesh：

Substances：

Year:  2017        PMID： 27670581     DOI： 10.2174/1389557516666160923125801

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  13 in total

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Journal:  Front Neurosci       Date:  2022-05-12       Impact factor: 5.152

4.  Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies.

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5.  Heterocyclic Substitutions Greatly Improve Affinity and Stability of Folic Acid towards FRα. an In Silico Insight.

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Journal:  Molecules       Date:  2021-02-18       Impact factor: 4.411

Review 6.  The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design.

Authors:  Yong Ling; Zhi-You Hao; Dong Liang; Chun-Lei Zhang; Yan-Fei Liu; Yan Wang
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Journal:  Front Pharmacol       Date:  2021-06-11       Impact factor: 5.810

8.  In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis.

Authors:  Katharigatta N Venugopala; Christophe Tratrat; Melendhran Pillay; Sandeep Chandrashekharappa; Omar Husham Ahmed Al-Attraqchi; Bandar E Aldhubiab; Mahesh Attimarad; Osama I Alwassil; Anroop B Nair; Nagaraja Sreeharsha; Rashmi Venugopala; Mohamed A Morsy; Michelyne Haroun; Hezekiel M Kumalo; Bharti Odhav; Koleka Mlisana
Journal:  Drug Des Devel Ther       Date:  2020-03-09       Impact factor: 4.162

9.  Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors.

Authors:  Monica-Cornelia Sardaru; Anda Mihaela Craciun; Cristina-Maria Al Matarneh; Isabela Andreea Sandu; Roxana Maria Amarandi; Lacramioara Popovici; Catalina Ionica Ciobanu; Dragos Peptanariu; Mariana Pinteala; Ionel I Mangalagiu; Ramona Danac
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

10.  Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity.

Authors:  Adel A-H Abdel-Rahman; Amira K F Shaban; Ibrahim F Nassar; Dina S El-Kady; Nasser S M Ismail; Samy F Mahmoud; Hanem M Awad; Wael A El-Sayed
Journal:  Molecules       Date:  2021-06-26       Impact factor: 4.411
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