| Literature DB >> 27668228 |
Zhongheng Zhang1, Qian Li2, Lingzhi Jiang2, Bo Xie3, Xiaowei Ji3, Jiahong Lu3, Ronglin Jiang4, Shu Lei4, Shihao Mao4, Lijun Ying5, Di Lu5, Xiaoshui Si6, Jianxin He6, Mingxia Ji6, Jianhua Zhu7, Guodong Chen7, Yadi Shao7, Yinghe Xu8, Ronghai Lin8, Chao Zhang8, Weiwen Zhang9, Jian Luo9, Tianzheng Lou10, Xuwei He10, Kun Chen1, Renhua Sun2.
Abstract
INTRODUCTION: Enteral feed is an important component of nutritional therapy in critically ill patients and underfeeding has been associated with adverse outcomes. The article developed an enteral feeding protocol and planed a before-and-after comparative trial to explore whether implementation of enteral feeding protocol was able to improve clinical outcomes. METHODS AND ANALYSIS: The study will be conducted in intensive care units (ICUs) of ten tertiary care academic centers. Critically ill patients expected to stay in ICU for over 3 days and require enteral nutrition (EN) were potentially eligible. This is a before-and-after study comprising three phases: The first phase is the period without enteral feeding protocol; the second phase involves four-week training program, and the last phase is to perform the protocol in participating centers. We plan to enroll a total of 350 patients to provide an 80% power and 0.05 error rate to detect a 15% reduction of mortality. The primary outcome is 28-day mortality. ETHICS AND DISSEMINATION: Ethical approval to conduct the research has been obtained from all participating centers. Additionally, the results will be published in peer-reviewed journal. TRIAL REGISTRATION: The study was registered at International Standard Registered Clinical/soCial sTudy Number (ISRCTN) registry (ISRCTN10583582).Entities:
Keywords: Enteral feeding; intensive care unit (ICU); mortality; prospective; protocol
Year: 2016 PMID： 27668228 PMCID： PMC5009025 DOI： 10.21037/atm.2016.07.15
Source DB: PubMed Journal: Ann Transl Med ISSN： 2305-5839