Literature DB >> 27668031

Assessing methods for generalizing experimental impact estimates to target populations.

Holger L Kern1, Elizabeth A Stuart2, Jennifer Hill3, Donald P Green4.   

Abstract

Randomized experiments are considered the gold standard for causal inference, as they can provide unbiased estimates of treatment effects for the experimental participants. However, researchers and policymakers are often interested in using a specific experiment to inform decisions about other target populations. In education research, increasing attention is being paid to the potential lack of generalizability of randomized experiments, as the experimental participants may be unrepresentative of the target population of interest. This paper examines whether generalization may be assisted by statistical methods that adjust for observed differences between the experimental participants and members of a target population. The methods examined include approaches that reweight the experimental data so that participants more closely resemble the target population and methods that utilize models of the outcome. Two simulation studies and one empirical analysis investigate and compare the methods' performance. One simulation uses purely simulated data while the other utilizes data from an evaluation of a school-based dropout prevention program. Our simulations suggest that machine learning methods outperform regression-based methods when the required structural (ignorability) assumptions are satisfied. When these assumptions are violated, all of the methods examined perform poorly. Our empirical analysis uses data from a multi-site experiment to assess how well results from a given site predict impacts in other sites. Using a variety of extrapolation methods, predicted effects for each site are compared to actual benchmarks. Flexible modeling approaches perform best, although linear regression is not far behind. Taken together, these results suggest that flexible modeling techniques can aid generalization while underscoring the fact that even state-of-the-art statistical techniques still rely on strong assumptions.

Entities:  

Year:  2016        PMID: 27668031      PMCID: PMC5030077          DOI: 10.1080/19345747.2015.1060282

Source DB:  PubMed          Journal:  J Res Educ Eff


  10 in total

1.  Matching methods for causal inference: A review and a look forward.

Authors:  Elizabeth A Stuart
Journal:  Stat Sci       Date:  2010-02-01       Impact factor: 2.901

2.  External Validity in Policy Evaluations that Choose Sites Purposively.

Authors:  Robert B Olsen; Larry L Orr; Stephen H Bell; Elizabeth A Stuart
Journal:  J Policy Anal Manage       Date:  2013

3.  The use of propensity scores to assess the generalizability of results from randomized trials.

Authors:  Elizabeth A Stuart; Stephen R Cole; Catherine P Bradshaw; Philip J Leaf
Journal:  J R Stat Soc Ser A Stat Soc       Date:  2001-04-01       Impact factor: 2.483

4.  Generalizing evidence from randomized clinical trials to target populations: The ACTG 320 trial.

Authors:  Stephen R Cole; Elizabeth A Stuart
Journal:  Am J Epidemiol       Date:  2010-06-14       Impact factor: 4.897

5.  Propensity score techniques and the assessment of measured covariate balance to test causal associations in psychological research.

Authors:  Valerie S Harder; Elizabeth A Stuart; James C Anthony
Journal:  Psychol Methods       Date:  2010-09

6.  Adjustment for selection bias in observational studies with application to the analysis of autopsy data.

Authors:  S Haneuse; J Schildcrout; P Crane; J Sonnen; J Breitner; E Larson
Journal:  Neuroepidemiology       Date:  2009-01-29       Impact factor: 3.282

7.  Evaluating bias correction in weighted proportional hazards regression.

Authors:  Qing Pan; Douglas E Schaubel
Journal:  Lifetime Data Anal       Date:  2008-10-29       Impact factor: 1.588

8.  Improving propensity score weighting using machine learning.

Authors:  Brian K Lee; Justin Lessler; Elizabeth A Stuart
Journal:  Stat Med       Date:  2010-02-10       Impact factor: 2.373

9.  Early intervention in low-birth-weight premature infants. Results through age 5 years from the Infant Health and Development Program.

Authors:  J Brooks-Gunn; C M McCarton; P H Casey; M C McCormick; C R Bauer; J C Bernbaum; J Tyson; M Swanson; F C Bennett; D T Scott
Journal:  JAMA       Date:  1994-10-26       Impact factor: 56.272

10.  Weight trimming and propensity score weighting.

Authors:  Brian K Lee; Justin Lessler; Elizabeth A Stuart
Journal:  PLoS One       Date:  2011-03-31       Impact factor: 3.240

  10 in total
  15 in total

1.  Transportability of Trial Results Using Inverse Odds of Sampling Weights.

Authors:  Daniel Westreich; Jessie K Edwards; Catherine R Lesko; Elizabeth Stuart; Stephen R Cole
Journal:  Am J Epidemiol       Date:  2017-10-15       Impact factor: 4.897

2.  Generalizability of heterogeneous treatment effect estimates across samples.

Authors:  Alexander Coppock; Thomas J Leeper; Kevin J Mullinix
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-16       Impact factor: 11.205

3.  Generalizing Treatment Effect Estimates From Sample to Population: A Case Study in the Difficulties of Finding Sufficient Data.

Authors:  Elizabeth A Stuart; Anna Rhodes
Journal:  Eval Rev       Date:  2016-08-04

4.  The Promise, and Challenges, of Methods to Enhance the External Validity of Randomized Trial Results.

Authors:  Elizabeth A Stuart; Catherine R Lesko
Journal:  Clin Pharmacol Ther       Date:  2020-08-08       Impact factor: 6.875

5.  Implementing statistical methods for generalizing randomized trial findings to a target population.

Authors:  Benjamin Ackerman; Ian Schmid; Kara E Rudolph; Marissa J Seamans; Ryoko Susukida; Ramin Mojtabai; Elizabeth A Stuart
Journal:  Addict Behav       Date:  2018-10-25       Impact factor: 3.913

6.  Comparison of Methods to Generalize Randomized Clinical Trial Results Without Individual-Level Data for the Target Population.

Authors:  Jin-Liern Hong; Michael Webster-Clark; Michele Jonsson Funk; Til Stürmer; Sara E Dempster; Stephen R Cole; Iksha Herr; Robert LoCasale
Journal:  Am J Epidemiol       Date:  2019-02-01       Impact factor: 4.897

7.  A data-zone scoring system to assess the generalizability of clinical trial results to individual patients.

Authors:  Luke J Laffin; Stephanie A Besser; Francis J Alenghat
Journal:  Eur J Prev Cardiol       Date:  2018-11-26       Impact factor: 7.804

8.  An outcome model approach to transporting a randomized controlled trial results to a target population.

Authors:  Benjamin A Goldstein; Matthew Phelan; Neha J Pagidipati; Rury R Holman; Michael J Pencina; Elizabeth A Stuart
Journal:  J Am Med Inform Assoc       Date:  2019-05-01       Impact factor: 4.497

9.  Generalizability of randomized trial results to target populations: Design and analysis possibilities.

Authors:  Elizabeth A Stuart; Benjamin Ackerman; Daniel Westreich
Journal:  Res Soc Work Pract       Date:  2017-07-27

10.  Target validity: Bringing treatment of external validity in line with internal validity.

Authors:  Catherine R Lesko; Benjamin Ackerman; Michael Webster-Clark; Jessie K Edwards
Journal:  Curr Epidemiol Rep       Date:  2020-06-30
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