Literature DB >> 27665717

ESX secretion systems: mycobacterial evolution to counter host immunity.

Matthias I Gröschel1,2, Fadel Sayes1, Roxane Simeone1, Laleh Majlessi1, Roland Brosch1.   

Abstract

Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as type VII secretion systems), to export a set of effector proteins that helps the pathogen to resist or evade the host immune response. Since the discovery of the esx loci during the M. tuberculosis H37Rv genome project, structural biology, cell biology and evolutionary analyses have advanced our knowledge of the function of these systems. In this Review, we highlight the intriguing roles that these studies have revealed for ESX systems in bacterial survival and pathogenicity during infection with M. tuberculosis. Furthermore, we discuss the diversity of ESX systems that has been described among mycobacteria and selected non-mycobacterial species. Finally, we consider how our knowledge of ESX systems might be applied to the development of novel strategies for the treatment and prevention of disease.

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Year:  2016        PMID： 27665717     DOI： 10.1038/nrmicro.2016.131

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN： 1740-1526            Impact factor:   60.633


  172 in total

1.  Composition of the type VII secretion system membrane complex.

Authors:  Edith N G Houben; Jovanka Bestebroer; Roy Ummels; Louis Wilson; Sander R Piersma; Connie R Jiménez; Tom H M Ottenhoff; Joen Luirink; Wilbert Bitter
Journal:  Mol Microbiol       Date:  2012-08-27       Impact factor: 3.501

2.  Staphylococcal Esx proteins modulate apoptosis and release of intracellular Staphylococcus aureus during infection in epithelial cells.

Authors:  Charalampia G Korea; Giuliana Balsamo; Alfredo Pezzicoli; Christina Merakou; Simona Tavarini; Fabio Bagnoli; Davide Serruto; Meera Unnikrishnan
Journal:  Infect Immun       Date:  2014-07-21       Impact factor: 3.441

Review 3.  Release of mycobacterial antigens.

Authors:  Laleh Majlessi; Rafael Prados-Rosales; Arturo Casadevall; Roland Brosch
Journal:  Immunol Rev       Date:  2015-03       Impact factor: 12.988

4.  The Type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis.

Authors:  Sarah A Stanley; James E Johndrow; Paolo Manzanillo; Jeffery S Cox
Journal:  J Immunol       Date:  2007-03-01       Impact factor: 5.422

5.  A specific secretion system mediates PPE41 transport in pathogenic mycobacteria.

Authors:  Abdallah M Abdallah; Theo Verboom; Fredericke Hannes; Mohamad Safi; Michael Strong; David Eisenberg; René J P Musters; Christina M J E Vandenbroucke-Grauls; Ben J Appelmelk; Joen Luirink; Wilbert Bitter
Journal:  Mol Microbiol       Date:  2006-11       Impact factor: 3.501

6.  Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria.

Authors:  Eva C Boritsch; Varun Khanna; Alexandre Pawlik; Nadine Honoré; Victor H Navas; Laurence Ma; Christiane Bouchier; Torsten Seemann; Philip Supply; Timothy P Stinear; Roland Brosch
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-15       Impact factor: 11.205

7.  The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response.

Authors:  Abdallah M Abdallah; Nigel D L Savage; Maaike van Zon; Louis Wilson; Christina M J E Vandenbroucke-Grauls; Nicole N van der Wel; Tom H M Ottenhoff; Wilbert Bitter
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

8.  Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking.

Authors:  Alka Mehra; Aleena Zahra; Victor Thompson; Natalie Sirisaengtaksin; Ashley Wells; Maura Porto; Stefan Köster; Kristen Penberthy; Yoshihisha Kubota; Amelie Dricot; Daniel Rogan; Marc Vidal; David E Hill; Andrew J Bean; Jennifer A Philips
Journal:  PLoS Pathog       Date:  2013-10-31       Impact factor: 6.823

9.  Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.

Authors:  Zijiang Zhao; Blima Fux; Megan Goodwin; Ildiko R Dunay; David Strong; Brian C Miller; Ken Cadwell; Monica A Delgado; Marisa Ponpuak; Karen G Green; Robert E Schmidt; Noboru Mizushima; Vojo Deretic; L David Sibley; Herbert W Virgin
Journal:  Cell Host Microbe       Date:  2008-11-13       Impact factor: 21.023

10.  Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.

Authors:  Jacqueline M Kimmey; Jeremy P Huynh; Leslie A Weiss; Sunmin Park; Amal Kambal; Jayanta Debnath; Herbert W Virgin; Christina L Stallings
Journal:  Nature       Date:  2015-12-09       Impact factor: 49.962
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  119 in total

Review 1.  Macrophage Signaling Pathways in Pulmonary Nontuberculous Mycobacteria Infections.

Authors:  Zohra Prasla; Roy L Sutliff; Ruxana T Sadikot
Journal:  Am J Respir Cell Mol Biol       Date:  2020-08       Impact factor: 6.914

Review 2.  Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1.

Authors:  Sangeeta Tiwari; Rosalyn Casey; Celia W Goulding; Suzie Hingley-Wilson; William R Jacobs
Journal:  Microbiol Spectr       Date:  2019-05

3.  Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.

Authors:  Katherine S H Beckham; Luciano Ciccarelli; Catalin M Bunduc; Haydyn D T Mertens; Roy Ummels; Wolfgang Lugmayr; Julia Mayr; Mandy Rettel; Mikhail M Savitski; Dmitri I Svergun; Wilbert Bitter; Matthias Wilmanns; Thomas C Marlovits; Annabel H A Parret; Edith N G Houben
Journal:  Nat Microbiol       Date:  2017-04-10       Impact factor: 17.745

4.  A New ESX-1 Substrate in Mycobacterium marinum That Is Required for Hemolysis but Not Host Cell Lysis.

Authors:  Rachel E Bosserman; Kathleen R Nicholson; Matthew M Champion; Patricia A Champion
Journal:  J Bacteriol       Date:  2019-06-21       Impact factor: 3.490

Review 5.  Life-Threatening Infections Due to Live-Attenuated Vaccines: Early Manifestations of Inborn Errors of Immunity.

Authors:  Laura Pöyhönen; Jacinta Bustamante; Jean-Laurent Casanova; Emmanuelle Jouanguy; Qian Zhang
Journal:  J Clin Immunol       Date:  2019-05-23       Impact factor: 8.317

Review 6.  Skin and Soft Tissue Infections Due to Nontuberculous Mycobacteria.

Authors:  Elizabeth Ann Misch; Christopher Saddler; James Muse Davis
Journal:  Curr Infect Dis Rep       Date:  2018-03-19       Impact factor: 3.725

7.  Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.

Authors:  Anne T Tuukkanen; Diana Freire; Sum Chan; Mark A Arbing; Robert W Reed; Timothy J Evans; Grasilda Zenkeviciutė; Jennifer Kim; Sara Kahng; Michael R Sawaya; Catherine T Chaton; Matthias Wilmanns; David Eisenberg; Annabel H A Parret; Konstantin V Korotkov
Journal:  J Mol Biol       Date:  2018-11-10       Impact factor: 5.469

Review 8.  Cure of tuberculosis using nanotechnology: An overview.

Authors:  Rout George Kerry; Sushanto Gouda; Bikram Sil; Gitishree Das; Han-Seung Shin; Gajanan Ghodake; Jayanta Kumar Patra
Journal:  J Microbiol       Date:  2018-05-02       Impact factor: 3.422

Review 9.  Type VII secretion systems: structure, functions and transport models.

Authors:  Angel Rivera-Calzada; Nikolaos Famelis; Oscar Llorca; Sebastian Geibel
Journal:  Nat Rev Microbiol       Date:  2021-05-26       Impact factor: 60.633

10.  Mycobacterium tuberculosis Requires Regulation of ESX-5 Secretion for Virulence in Irgm1-Deficient Mice.

Authors:  Sarah R Elliott; Dylan W White; Anna D Tischler
Journal:  Infect Immun       Date:  2019-01-24       Impact factor: 3.441
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