Elza Márcia Yacubian1. 1. Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address: yacubian@terra.com.br.
Abstract
PURPOSE: Since its initial 1957 description, juvenile myoclonic epilepsy (JME) has been recognized as a common epileptic syndrome worldwide. METHODS: We reviewed a series of articles on JME to clarify challenges in clinical and pathophysiological findings, treatment and outcome. RESULTS: Typical JME characteristics include: 1) the age at seizure onset between 10 and 25 years; 2) the triad of myoclonia, generalized tonic-clonic seizures, and absences, of which only myoclonia is a mandatory criterion; 3) cognitive dysfunction that may have impact on interpersonal relationships and social outcome; 4) possibility of seizure control in up to 80% of individuals, in particular with the use of sodium valproate; 5) a tendency for lifelong seizures with an early morning preponderance; 6) after decades from the clinical onset, a possibility to be off medications for a third of the patients, and 7) several prognostic factors. CONCLUSION: After 60 years, several challenges remain in this complex epileptic syndrome.
PURPOSE: Since its initial 1957 description, juvenile myoclonic epilepsy (JME) has been recognized as a common epileptic syndrome worldwide. METHODS: We reviewed a series of articles on JME to clarify challenges in clinical and pathophysiological findings, treatment and outcome. RESULTS: Typical JME characteristics include: 1) the age at seizure onset between 10 and 25 years; 2) the triad of myoclonia, generalized tonic-clonic seizures, and absences, of which only myoclonia is a mandatory criterion; 3) cognitive dysfunction that may have impact on interpersonal relationships and social outcome; 4) possibility of seizure control in up to 80% of individuals, in particular with the use of sodium valproate; 5) a tendency for lifelong seizures with an early morning preponderance; 6) after decades from the clinical onset, a possibility to be off medications for a third of the patients, and 7) several prognostic factors. CONCLUSION: After 60 years, several challenges remain in this complex epileptic syndrome.
Authors: F Wielaender; F M K James; M A Cortez; G Kluger; J N Neßler; A Tipold; H Lohi; A Fischer Journal: J Vet Intern Med Date: 2017-11-30 Impact factor: 3.333
Authors: Emily A F Holmes; Catrin Plumpton; Gus A Baker; Ann Jacoby; Adele Ring; Paula Williamson; Anthony Marson; Dyfrig A Hughes Journal: Clin Pharmacol Ther Date: 2018-10-25 Impact factor: 6.875