Yue Guan1, Weifeng Li1, Zhuoran Jiang1, Ying Chen1, Song Liu2, Jian He3, Zhengyang Zhou4, Yun Ge5. 1. School of Electronic Science and Engineering, Nanjing University, No. 163 Xianlin Road, Nanjing 210046, China. 2. Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, China. 3. Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, China. Electronic address: hjxueren@163.com. 4. Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, China. Electronic address: zyzhou@nju.edu.cn. 5. School of Electronic Science and Engineering, Nanjing University, No. 163 Xianlin Road, Nanjing 210046, China. Electronic address: geyunnju@126.com.
Abstract
RATIONALE AND OBJECTIVES: This study aimed to develop whole-lesion apparent diffusion coefficient (ADC)-based entropy-related parameters of cervical cancer to preliminarily assess intratumoral heterogeneity of this lesion in comparison to adjacent normal cervical tissues. MATERIALS AND METHODS: A total of 51 women (mean age, 49 years) with cervical cancers confirmed by biopsy underwent 3-T pelvic diffusion-weighted magnetic resonance imaging with b values of 0 and 800 s/mm2 prospectively. ADC-based entropy-related parameters including first-order entropy and second-order entropies were derived from the whole tumor volume as well as adjacent normal cervical tissues. Intraclass correlation coefficient, Wilcoxon test with Bonferroni correction, Kruskal-Wallis test, and receiver operating characteristic curve were used for statistical analysis. RESULTS: All the parameters showed excellent interobserver agreement (all intraclass correlation coefficients > 0.900). Entropy, entropy(H)0, entropy(H)45, entropy(H)90, entropy(H)135, and entropy(H)mean were significantly higher, whereas entropy(H)range and entropy(H)std were significantly lower in cervical cancers compared to adjacent normal cervical tissues (all P <.0001). Kruskal-Wallis test showed that there were no significant differences among the values of various second-order entropies including entropy(H)0, entropy(H)45, entropy(H)90, entropy(H)135, and entropy(H)mean. All second-order entropies had larger area under the receiver operating characteristic curve than first-order entropy in differentiating cervical cancers from adjacent normal cervical tissues. Further, entropy(H)45, entropy(H)90, entropy(H)135, and entropy(H)mean had the same largest area under the receiver operating characteristic curve of 0.867. CONCLUSION: Whole-lesion ADC-based entropy-related parameters of cervical cancers were developed successfully, which showed initial potential in characterizing intratumoral heterogeneity in comparison to adjacent normal cervical tissues.
RATIONALE AND OBJECTIVES: This study aimed to develop whole-lesion apparent diffusion coefficient (ADC)-based entropy-related parameters of cervical cancer to preliminarily assess intratumoral heterogeneity of this lesion in comparison to adjacent normal cervical tissues. MATERIALS AND METHODS: A total of 51 women (mean age, 49 years) with cervical cancers confirmed by biopsy underwent 3-T pelvic diffusion-weighted magnetic resonance imaging with b values of 0 and 800 s/mm2 prospectively. ADC-based entropy-related parameters including first-order entropy and second-order entropies were derived from the whole tumor volume as well as adjacent normal cervical tissues. Intraclass correlation coefficient, Wilcoxon test with Bonferroni correction, Kruskal-Wallis test, and receiver operating characteristic curve were used for statistical analysis. RESULTS: All the parameters showed excellent interobserver agreement (all intraclass correlation coefficients > 0.900). Entropy, entropy(H)0, entropy(H)45, entropy(H)90, entropy(H)135, and entropy(H)mean were significantly higher, whereas entropy(H)range and entropy(H)std were significantly lower in cervical cancers compared to adjacent normal cervical tissues (all P <.0001). Kruskal-Wallis test showed that there were no significant differences among the values of various second-order entropies including entropy(H)0, entropy(H)45, entropy(H)90, entropy(H)135, and entropy(H)mean. All second-order entropies had larger area under the receiver operating characteristic curve than first-order entropy in differentiating cervical cancers from adjacent normal cervical tissues. Further, entropy(H)45, entropy(H)90, entropy(H)135, and entropy(H)mean had the same largest area under the receiver operating characteristic curve of 0.867. CONCLUSION: Whole-lesion ADC-based entropy-related parameters of cervical cancers were developed successfully, which showed initial potential in characterizing intratumoral heterogeneity in comparison to adjacent normal cervical tissues.
Authors: Yan Yan Yu; Rui Zhang; Rui Tong Dong; Qi Yun Hu; Tao Yu; Fan Liu; Ya Hong Luo; Yue Dong Journal: Br J Radiol Date: 2019-04-01 Impact factor: 3.039