| Literature DB >> 27664935 |
Maria Anastasina1, Nicolas Le May2, Andrii Bugai3, Yu Fu4, Sandra Söderholm5, Lana Gaelings4, Tiina Ohman5, Janne Tynell6, Suvi Kyttänen4, Matjaz Barboric3, Tuula A Nyman7, Sampsa Matikainen3, Ilkka Julkunen8, Sarah J Butcher5, Jean-Marc Egly9, Denis E Kainov10.
Abstract
Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication.Entities:
Keywords: Antiviral responses; Influenza A virus; Innate immunity; Regulation of gene expression; Viral counter-responses
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Year: 2016 PMID： 27664935 DOI： 10.1016/j.bbagrm.2016.09.005
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002