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Literature DB >> 27663990

Regulation of pulmonary endothelial barrier function by kinases.

Nektarios Barabutis¹, Alexander Verin², John D Catravas^3,4.

Abstract

The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

Keywords: barrier function; endothelium; kinases; lung; permeability

Mesh：

Substances：
Protein Kinases

Year: 2016 PMID： 27663990 PMCID： PMC5130537 DOI： 10.1152/ajplung.00233.2016

Source DB: PubMed Journal: Am J Physiol Lung Cell Mol Physiol ISSN： 1040-0605 Impact factor: 5.464

275 in total

Review 1. Signaling through focal adhesion kinase.

Authors: D D Schlaepfer; C R Hauck; D J Sieg
Journal: Prog Biophys Mol Biol Date: 1999 Impact factor: 3.667

2. Gp60 activation mediates albumin transcytosis in endothelial cells by tyrosine kinase-dependent pathway.

Authors: C Tiruppathi; W Song; M Bergenfeldt; P Sass; A B Malik
Journal: J Biol Chem Date: 1997-10-10 Impact factor: 5.157

Review 3. Breaking the VE-cadherin bonds.

Authors: Julie Gavard
Journal: FEBS Lett Date: 2008-12-04 Impact factor: 4.124

4. Thrombin and histamine phosphorylate the 42 kDa mitogen-activated protein kinase in HUVEC.

Authors: C P Wheeler-Jones; J D Pearson
Journal: Biochem Soc Trans Date: 1995-05 Impact factor: 5.407

5. Increased permeability of primary cultured brain microvessel endothelial cell monolayers following TNF-alpha exposure.

Authors: K S Mark; D W Miller
Journal: Life Sci Date: 1999 Impact factor: 5.037

6. Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity.

Authors: K Ichikawa; M Ito; D J Hartshorne
Journal: J Biol Chem Date: 1996-03-01 Impact factor: 5.157

7. Mitogen-activated protein kinases regulate platelet-activating factor-induced hyperpermeability.

Authors: Peng Yu; Takuya Hatakeyama; Haruo Aramoto; Tetsuro Miyata; Hiroshi Shigematsu; Hirokazu Nagawa; Robert W Hobson; Walter N Durán
Journal: Microcirculation Date: 2005-12 Impact factor: 2.628

Review 8. Endothelial focal adhesions and barrier function.

Authors: Mack H Wu
Journal: J Physiol Date: 2005-09-29 Impact factor: 5.182

9. Protein kinases as mediators of fluid shear stress stimulated signal transduction in endothelial cells: a hypothesis for calcium-dependent and calcium-independent events activated by flow.

Authors: B C Berk; M A Corson; T E Peterson; H Tseng
Journal: J Biomech Date: 1995-12 Impact factor: 2.712

10. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma.

Authors: Seoung Ju Park; Kyung Sun Lee; So Ri Kim; Han Jung Chae; Wan Hee Yoo; Dong Im Kim; Myoung Shin Jeon; Yong Chul Lee
Journal: Inflamm Res Date: 2012-06-13 Impact factor: 4.575

26 in total

1. Hydrocortisone and Ascorbic Acid Synergistically Prevent and Repair Lipopolysaccharide-Induced Pulmonary Endothelial Barrier Dysfunction.

Authors: Nektarios Barabutis; Vikramjit Khangoora; Paul E Marik; John D Catravas
Journal: Chest Date: 2017-07-21 Impact factor: 9.410

Regulation of pulmonary endothelial barrier function by kinases.

Review 1. Signaling through focal adhesion kinase.

2. Gp60 activation mediates albumin transcytosis in endothelial cells by tyrosine kinase-dependent pathway.

Review 3. Breaking the VE-cadherin bonds.

4. Thrombin and histamine phosphorylate the 42 kDa mitogen-activated protein kinase in HUVEC.

5. Increased permeability of primary cultured brain microvessel endothelial cell monolayers following TNF-alpha exposure.

6. Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity.

7. Mitogen-activated protein kinases regulate platelet-activating factor-induced hyperpermeability.

Review 8. Endothelial focal adhesions and barrier function.

9. Protein kinases as mediators of fluid shear stress stimulated signal transduction in endothelial cells: a hypothesis for calcium-dependent and calcium-independent events activated by flow.

10. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma.

1. Hydrocortisone and Ascorbic Acid Synergistically Prevent and Repair Lipopolysaccharide-Induced Pulmonary Endothelial Barrier Dysfunction.

2. Autophagy, Unfolded Protein Response and Lung Disease.

3. P53 supports endothelial barrier function via APE1/Ref1 suppression.

4. Hsp90 inhibitors suppress P53 phosphorylation in LPS - induced endothelial inflammation.

5. GHRH antagonists support lung endothelial barrier function.

6. P53: The endothelium defender.

7. Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation.

Review 8. Unfolded Protein Response supports endothelial barrier function.

9. Unfolded protein response regulates P53 expression in the pulmonary endothelium.

10. Arg mediates LPS-induced disruption of the pulmonary endothelial barrier.