Literature DB >> 27663887

Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis.

Ho Jeon Young1, Jung Weon Lee2, Sunghoon Kim3.   

Abstract

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that conjugate specific amino acids to their cognate tRNAs for protein synthesis. Besides their catalytic activity, recent studies have uncovered many additional functions of these enzymes through their interactions with diverse cellular factors. Among human ARSs, cytosolic lysyl-tRNA synthetase (KRS) is often highly expressed in cancer cells and tissues, and facilitates cancer cell migration and invasion through the interaction with the 67kDa laminin receptor on the plasma membrane. Specific modulation of this interaction by small molecule inhibitors has revealed a new way to control metastasis. Here, we summarize the pro-metastatic functions of KRS and their patho-physiological implications.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Anti-cancer drug; Cancer metastasis; Laminin receptor; Lysyl-tRNA synthetase; Membrane localization; Protein-protein interaction

Mesh：

Substances：

Year:  2016        PMID： 27663887     DOI： 10.1016/j.bbapap.2016.09.009

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  7 in total

1.  MARS variant associated with both recessive interstitial lung and liver disease and dominant Charcot-Marie-Tooth disease.

Authors:  Jonathan Rips; Rebecca Meyer-Schuman; Oded Breuer; Reuven Tsabari; Avraham Shaag; Shoshana Revel-Vilk; Shimon Reif; Orly Elpeleg; Anthony Antonellis; Tamar Harel
Journal:  Eur J Med Genet       Date:  2018-04-12       Impact factor: 2.708

2.  Lysyl-tRNA synthetase-expressing colon spheroids induce M2 macrophage polarization to promote metastasis.

Authors:  Seo Hee Nam; Doyeun Kim; Doohyung Lee; Hye-Mi Lee; Dae-Geun Song; Jae Woo Jung; Ji Eon Kim; Hye-Jin Kim; Nam Hoon Kwon; Eun-Kyeong Jo; Sunghoon Kim; Jung Weon Lee
Journal:  J Clin Invest       Date:  2018-10-08       Impact factor: 14.808

3.  Embryonic transcriptome and proteome analyses on hepatic lipid metabolism in chickens divergently selected for abdominal fat content.

Authors:  Wei Na; Yuan-Yuan Wu; Peng-Fei Gong; Chun-Yan Wu; Bo-Han Cheng; Yu-Xiang Wang; Ning Wang; Zhi-Qiang Du; Hui Li
Journal:  BMC Genomics       Date:  2018-05-23       Impact factor: 3.969

4.  Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.

Authors:  Hui Tian; Hao Yan; Yong Zhang; Qiaofen Fu; Chunyan Li; Juan He; Hui Li; Yong Zhou; Youguang Huang; Rongqing Li
Journal:  Bioengineered       Date:  2022-03       Impact factor: 3.269

Review 5.  The pLysRS-Ap4A Pathway in Mast Cells Regulates the Switch from Host Defense to a Pathological State.

Authors:  Sharmila Govindaraj; Lakshmi Bhargavi Paruchuru; Ehud Razin
Journal:  Int J Mol Sci       Date:  2021-05-25       Impact factor: 5.923

6.  Three human aminoacyl-tRNA synthetases have distinct sub-mitochondrial localizations that are unaffected by disease-associated mutations.

Authors:  Ligia Elena González-Serrano; Loukmane Karim; Florian Pierre; Hagen Schwenzer; Agnès Rötig; Arnold Munnich; Marie Sissler
Journal:  J Biol Chem       Date:  2018-07-13       Impact factor: 5.157

7.  Threonyl-tRNA Synthetase Promotes T Helper Type 1 Cell Responses by Inducing Dendritic Cell Maturation and IL-12 Production via an NF-κB Pathway.

Authors:  Hak-Jun Jung; Su-Ho Park; Kyung-Min Cho; Kwang Il Jung; Daeho Cho; Tae Sung Kim
Journal:  Front Immunol       Date:  2020-10-14       Impact factor: 7.561
  7 in total

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