| Literature DB >> 27663743 |
Weijing Han1, Shaohua Chen2, Wei Yuan3, Qihui Fan1, Jianxiang Tian2, Xiaochen Wang1, Longqing Chen4, Xixiang Zhang5, Weili Wei5, Ruchuan Liu6, Junle Qu3, Yang Jiao2, Robert H Austin7, Liyu Liu8.
Abstract
In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).Entities:
Keywords: cancer; collagen; intravasation; microenvironment; oriented invasion
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Year: 2016 PMID： 27663743 PMCID： PMC5056065 DOI： 10.1073/pnas.1610347113
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205