Literature DB >> 27663671

Mono- and quadri-subtype virus-like particles (VLPs) containing H10 subtype elicit protective immunity to H10 influenza in a ferret challenge model.

Peter Pushko1, Xiangjie Sun2, Irina Tretyakova3, Rachmat Hidajat3, Joanna A Pulit-Penaloza2, Jessica A Belser2, Taronna R Maines2, Terrence M Tumpey2.   

Abstract

Avian-origin influenza represents a global public health concern. In 2013, the H10N8 virus caused documented human infections for the first time. Currently, there is no approved vaccine against H10 influenza. Recombinant virus-like particles (VLPs) represent a promising vaccine approach. In this study, we evaluated H10 VLPs containing hemagglutinin from H10N8 virus as an experimental vaccine in a ferret challenge model. In addition, we evaluated quadri-subtype VLPs co-localizing H5, H7, H9 and H10 subtypes. Both vaccines elicited serum antibody that reacted with the homologous H10 derived from H10N8 virus and cross-reacted with the heterologous H10N1 virus. Quadri-subtype vaccine also elicited serum antibody to the homologous H5, H7, and H9 antigens and cross-reacted with multiple clades of H5N1 virus. After heterologous challenge with the H10N1 virus, all vaccinated ferrets showed significantly reduced titers of replicating virus in the respiratory tract indicating protective effect of vaccination with either H10 VLPs or with quadri-subtype VLPs.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Baculovirus; H10N8; Influenza; Recombinant vaccine; VLP; Virus-like particles

Mesh：

Substances：

Year:  2016        PMID： 27663671      PMCID： PMC5063076          DOI： 10.1016/j.vaccine.2016.09.012

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  45 in total

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2.  Influenza virus-like particle can accommodate multiple subtypes of hemagglutinin and protect from multiple influenza types and subtypes.

Authors:  Peter Pushko; Melissa B Pearce; Attiya Ahmad; Irina Tretyakova; Gale Smith; Jessica A Belser; Terrence M Tumpey
Journal:  Vaccine       Date:  2011-06-30       Impact factor: 3.641

3.  Evaluation of influenza virus-like particles and Novasome adjuvant as candidate vaccine for avian influenza.

Authors:  Peter Pushko; Terrence M Tumpey; Neal Van Hoeven; Jessica A Belser; Robin Robinson; Margret Nathan; Gale Smith; D Craig Wright; Rick A Bright
Journal:  Vaccine       Date:  2007-03-09       Impact factor: 3.641

4.  Vaccination with virus-like particles containing H5 antigens from three H5N1 clades protects chickens from H5N1 and H5N8 influenza viruses.

Authors:  Darrell R Kapczynski; Terrence M Tumpey; Rachmat Hidajat; Aniko Zsak; Klaudia Chrzastek; Irina Tretyakova; Peter Pushko
Journal:  Vaccine       Date:  2016-02-08       Impact factor: 3.641

5.  Virus-like particle vaccine protects against 2009 H1N1 pandemic influenza virus in mice.

Authors:  Fu-Shi Quan; Aswani Vunnava; Richard W Compans; Sang-Moo Kang
Journal:  PLoS One       Date:  2010-02-11       Impact factor: 3.240

6.  Preparation of quadri-subtype influenza virus-like particles using bovine immunodeficiency virus gag protein.

Authors:  Irina Tretyakova; Rachmat Hidajat; Garrett Hamilton; Noah Horn; Brian Nickols; Raphael O Prather; Terrence M Tumpey; Peter Pushko
Journal:  Virology       Date:  2015-11-02       Impact factor: 3.616

Review 7.  Making better influenza virus vaccines?

Authors:  Peter Palese
Journal:  Emerg Infect Dis       Date:  2006-01       Impact factor: 6.883

8.  Broadly protective adenovirus-based multivalent vaccines against highly pathogenic avian influenza viruses for pandemic preparedness.

Authors:  Sai V Vemula; Yadvinder S Ahi; Anne-Marie Swaim; Jacqueline M Katz; Ruben Donis; Suryaprakash Sambhara; Suresh K Mittal
Journal:  PLoS One       Date:  2013-04-30       Impact factor: 3.240

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Authors:  Suxiang Tong; Xueyong Zhu; Yan Li; Mang Shi; Jing Zhang; Melissa Bourgeois; Hua Yang; Xianfeng Chen; Sergio Recuenco; Jorge Gomez; Li-Mei Chen; Adam Johnson; Ying Tao; Cyrille Dreyfus; Wenli Yu; Ryan McBride; Paul J Carney; Amy T Gilbert; Jessie Chang; Zhu Guo; Charles T Davis; James C Paulson; James Stevens; Charles E Rupprecht; Edward C Holmes; Ian A Wilson; Ruben O Donis
Journal:  PLoS Pathog       Date:  2013-10-10       Impact factor: 6.823

10.  Seasonal influenza vaccination is the strongest correlate of cross-reactive antibody responses in migratory bird handlers.

Authors:  Christine M Oshansky; Sook-San Wong; Trushar Jeevan; Heather S Smallwood; Richard J Webby; Shira C Shafir; Paul G Thomas
Journal:  MBio       Date:  2014-12-09       Impact factor: 7.867
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  7 in total

1.  Multi-clade H5N1 virus-like particles: Immunogenicity and protection against H5N1 virus and effects of beta-propiolactone.

Authors:  Peter Pushko; Irina Tretyakova; Rachmat Hidajat; Xiangjie Sun; Jessica A Belser; Terrence M Tumpey
Journal:  Vaccine       Date:  2018-06-07       Impact factor: 3.641

2.  Evaluation of the Biological Properties and Cross-Reactive Antibody Response to H10 Influenza Viruses in Ferrets.

Authors:  Troy C Sutton; Elaine W Lamirande; Rita Czako; Kanta Subbarao
Journal:  J Virol       Date:  2017-09-12       Impact factor: 5.103

3.  Virus-like particles displaying H5, H7, H9 hemagglutinins and N1 neuraminidase elicit protective immunity to heterologous avian influenza viruses in chickens.

Authors:  Peter Pushko; Irina Tretyakova; Rachmat Hidajat; Aniko Zsak; Klaudia Chrzastek; Terrence M Tumpey; Darrell R Kapczynski
Journal:  Virology       Date:  2016-12-06       Impact factor: 3.616

4.  Dual-linker gold nanoparticles as adjuvanting carriers for multivalent display of recombinant influenza hemagglutinin trimers and flagellin improve the immunological responses in vivo and in vitro.

Authors:  Chao Wang; Wandi Zhu; Bao-Zhong Wang
Journal:  Int J Nanomedicine       Date:  2017-07-04

5.  A peptide-based approach to evaluate the adaptability of influenza A virus to humans based on its hemagglutinin proteolytic cleavage site.

Authors:  Marco R Straus; Gary R Whittaker
Journal:  PLoS One       Date:  2017-03-30       Impact factor: 3.240

6.  The Emergence and Zoonotic Transmission of H10Nx Avian Influenza Virus Infections.

Authors:  Holly Everest; Elizabeth Billington; Rebecca Daines; Alice Burman; Munir Iqbal
Journal:  mBio       Date:  2021-09-07       Impact factor: 7.867

Review 7.  Influenza Virus Like Particles (VLPs): Opportunities for H7N9 Vaccine Development.

Authors:  Peter Pushko; Irina Tretyakova
Journal:  Viruses       Date:  2020-05-08       Impact factor: 5.048
  7 in total

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