PURPOSE OF REVIEW: The goal of this review was to systematically analyze recent studies updating our knowledge on the role of epigenetic mechanisms in childhood asthma. RECENT FINDINGS: A systematic literature search was conducted that identified 23 fresh articles published within the last 5 years reporting the results of human studies on the relationships between epigenetic modifications and childhood asthma or its/related phenotypes. In almost all these studies, meaningful associations between levels of epigenetic marks (DNA methylation and/or histone modifications) and pediatric asthma or its/related phenotypes have been observed. In addition, many studies identified by our screening analyzed those associations in the context of environmental factors, such as pollution, tobacco smoke, farming, or diet, showing in a huge majority a modifying effect of those exposures. SUMMARY: The results of our systematic literature search provide a strong support for the role of epigenetic mechanisms in (mediating the effects of environmental exposure on) pediatric asthma. This knowledge may possibly be translated into diagnostic and/or therapeutic approaches.
PURPOSE OF REVIEW: The goal of this review was to systematically analyze recent studies updating our knowledge on the role of epigenetic mechanisms in childhood asthma. RECENT FINDINGS: A systematic literature search was conducted that identified 23 fresh articles published within the last 5 years reporting the results of human studies on the relationships between epigenetic modifications and childhood asthma or its/related phenotypes. In almost all these studies, meaningful associations between levels of epigenetic marks (DNA methylation and/or histone modifications) and pediatric asthma or its/related phenotypes have been observed. In addition, many studies identified by our screening analyzed those associations in the context of environmental factors, such as pollution, tobacco smoke, farming, or diet, showing in a huge majority a modifying effect of those exposures. SUMMARY: The results of our systematic literature search provide a strong support for the role of epigenetic mechanisms in (mediating the effects of environmental exposure on) pediatric asthma. This knowledge may possibly be translated into diagnostic and/or therapeutic approaches.
Authors: Xue Zhang; Jocelyn M Biagini Myers; J D Burleson; Ashley Ulm; Kelly S Bryan; Xiaoting Chen; Matthew T Weirauch; Theresa A Baker; Melinda S Butsch Kovacic; Hong Ji Journal: Epigenomics Date: 2018-04-25 Impact factor: 4.778
Authors: Kenneth R Eyring; Brent S Pedersen; Kenneth N Maclean; Sally P Stabler; Ivana V Yang; David A Schwartz Journal: PLoS One Date: 2018-01-12 Impact factor: 3.240
Authors: Hani Harb; James Irvine; Manori Amarasekera; Charles S Hii; Dörthe A Kesper; YueFang Ma; Nina D'Vaz; Harald Renz; Daniel P Potaczek; Susan L Prescott; Antonio Ferrante Journal: Biosci Rep Date: 2017-03-27 Impact factor: 3.840
Authors: Bilal Alaskhar Alhamwe; Razi Khalaila; Johanna Wolf; Harald Renz; Holger Garn; Daniel P Potaczek; Verena von Bülow; Hani Harb; Fahd Alhamdan; Charles S Hii; Susan L Prescott; Antonio Ferrante Journal: Allergy Asthma Clin Immunol Date: 2018-05-23 Impact factor: 3.406
Authors: Hani Harb; Bilal Alashkar Alhamwe; Daniel P Potaczek; Annika Scheynius; Nathalie Acevedo; Paolo Frumento; Catharina Johansson; Lisa Eick; Nikos Papadogiannakis; Johan Alm; Harald Renz Journal: Biomed Res Int Date: 2019-04-17 Impact factor: 3.411
Authors: Nathalie Acevedo; Bilal Alashkar Alhamwe; Luis Caraballo; Mei Ding; Antonio Ferrante; Holger Garn; Johan Garssen; Charles S Hii; James Irvine; Kevin Llinás-Caballero; Juan Felipe López; Sarah Miethe; Khalida Perveen; Elke Pogge von Strandmann; Milena Sokolowska; Daniel P Potaczek; Betty C A M van Esch Journal: Nutrients Date: 2021-02-25 Impact factor: 5.717
Authors: Bilal Alashkar Alhamwe; Sarah Miethe; Elke Pogge von Strandmann; Daniel P Potaczek; Holger Garn Journal: Front Immunol Date: 2020-08-18 Impact factor: 7.561